Harmonization in Interspecies Extrapolation: Use of BW 3/4 as Default Method in Derivation of the Oral RfD (External Review Draft)
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EPA has released for independent external peer review and a 60-day public comment period, a draft report entitled Harmonization in Interspecies Extrapolation: Use of BW3/4 as Default Method in Derivation of the Oral RfD. When data from experiments using laboratory animals are used for evaluating human health risks, an adjustment for differences among species, usually called an interspecies extrapolation, is made to determine a human equivalent exposure. For the inhalation route of exposure, this issue was addressed in the 1994 EPA document Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. This draft report focuses on the oral route of exposure.
|Mar 2005||EPA published the EPA Cancer Guidelines (Final 2005)|
|Feb 2006||EPA release the first External Peer Review Draft (ERD) for public comment.|
|Dec 2008||EPA's RAF program moved this draft report to the Office of the Science Advisor's Web site at http://www.epa.gov/raf/publications/interspecies-extrapolation.htm.|
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