US EPA

In April 2021, EPA released the Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols communicate the rationale for conducting the assessment of vanadium and compounds (oral), describe screening criteria to identify relevant literature, outline the approach for evaluating study quality, and describe the dose-response methods.

Vanadium is a naturally occurring metal that is the 22nd most abundant element in the earth’s crust and is found in a variety of minerals and nearly all coal and petroleum crude oils. Oral exposure to vanadium may occur naturally (e.g., foods) or anthropogenically via contamination of soil, surface waters, or groundwater.

This document presents a draft assessment plan for vanadium and compounds (oral exposure) that will be the subject of a peer review meeting in 20/21 and that will define the scope and approach of the IRIS assessment for vanadium and compounds (oral exposure).

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.

U.S. EPA. Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-21/047, 2021.