US EPA

In April 2023, the IRIS Program released the draft IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts for public comment and external peer review. The IRIS assessment of PFDA will undergo an independent external scientific peer review managed by ERG, a contractor to EPA. Additional information about the peer review meeting is listed with the downloads below and located on the external peer review meeting site.

Perfluorodecanoic Acid (PFDA) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water. Concerns about PFDA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment. PFDA has been used in stain and grease-proof coatings on food packaging, furniture, upholstery, and carpet. PFDA has also been detected in nano- and impregnation-sprays, outdoor textiles, carpet, gloves, paper-based food contact materials, ski wax, and leather. Exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFDA-containing products.

This document presents a draft assessment plan for the PFDA assessment that will be the subject of an SAB/Chemical Assessment Advisory Committee review which will define the scope and approach of the IRIS assessment for this chemical.

The toxicological review of PFDA and related salts was released for a 60-day public comment period and external peer review. Following the external peer review meeting, the assessment will be revised, taking into consideration all public and external peer review comments received.

U.S. EPA. IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Public Comment and External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-23/056a, 2023.

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