Inhibition Of The Sodium-Iodide Symporter By Perchlorate: An Evaluation Of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (Pbpk) Modeling (External Review Draft)
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Abstract
EPA first released this document in draft form as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. The document has since been revised. The final report is available in response to comments from independent external peer review. A copy of the PBPK model code is available. In addition, the final peer review report and a summary of external peer review comments and EPA responses are available.
This report provides an analysis of perchlorate-mediated inhibition of the sodium-iodide symporter (NIS) in humans using published PBPK models, focusing on the degree of NIS inhibition as a function of lifestage. The models provide information that may be used to address differences in human responses to perchlorate across lifestages.
This report provides an analysis of perchlorate-mediated inhibition of the sodium-iodide symporter (NIS) in humans using published PBPK models, focusing on the degree of NIS inhibition as a function of lifestage. The models provide information that may be used to address differences in human responses to perchlorate across lifestages.
Impact/Purpose
The report was subjected to external peer review and has been released with an FRN by the Office of Water, accompanying a regulatory determination.
Status
Following the external peer review, EPA plans to release a revised final document.
Citation
U.S. EPA. Inhibition Of The Sodium-Iodide Symporter By Perchlorate: An Evaluation Of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (Pbpk) Modeling (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-08/106A, 2008.
History/Chronology
| Date | Description |
|---|---|
| Oct 2008 | EPA released an external review draft for public review and comment as a supporting document to the EPA Drinking Water Ruling. |
| Dec 2008 | EPA released the consolidated comments from the independent external peer review. |
| Aug 2009 | EPA released the summary of external peer review comments and disposition for the 2008 external review draft of the report with the draft report. |
| Aug 2009 | EPA publishes the final report. |
- Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (External Review Draft) (PDF) (68 pp, 14 MB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (145 pp, 1 MB, about PDF)
- Summary of External Peer Review Comments and Disposition for the 2008 external review draft of the report Inhibition of the Sodium-Iodide Symporter by Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically-based Pharmacokinetic (PBPK) Modeling (PDF) (34 pp, 288 KB, about PDF)