REGULATORY HISTORY AND EXPERIMENTAL SUPPORT OF UNCERTAINTY (SAFETY) FACTORS
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
A synthesis of available literature on uncertainty (safety) factors which are used to estimate acceptable daily intakes (ADIs) for toxicants is presented. The synthesis reveals reasonable qualitative biological premises, as well as specific biological data that support both the use and choice of these factors. A suggestion is made in order to derive a range of ADI. Research needs in various areas of uncertainty are also identified.
Citation
Dourson, M. AND J. Stara. REGULATORY HISTORY AND EXPERIMENTAL SUPPORT OF UNCERTAINTY (SAFETY) FACTORS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/315 (NTIS PB86100310).
Additional Information
Pub. in Regulatory Toxicology and Pharmacology 3, p224-238 1983.