Grantee Research Project Results
Center for Children's Health, the Environment, Microbiome, and Metabolomics
EPA Grant Number: R836153Center: Center for Children’s Health, the Environment, Microbiome, and Metabolomics’ Center
Center Director: McCauley, Linda
Title: Center for Children's Health, the Environment, Microbiome, and Metabolomics
Investigators: McCauley, Linda
Current Investigators: McCauley, Linda , Ryan, P. Barry
Institution: Emory University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2020)
Project Amount: $1,797,870
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
The overall goal of this Center is to assess the influence of the environmental exposures of pregnant women on their microbiome and the subsequent impact of the mother’s microbiome on neurodevelopment of the fetus and infant.
Approach:
Emory University’s “Center for Children’s Health, the Environment, Microbiome, and Metabolomics (CCHEM2) will conduct research on how environmental exposures influence the microbiome of infants and children and the subsequent influence of changes in the microbiome on neurodevelopment. The establishment of a center focused on the microbiome is significant given that the microbiome is established during the first years of life when development is highly sensitive to the effects of environmental exposures. This interdisciplinary center will conduct studies on exposures in an urban environment, the microbiome of pregnant women and their infants, and associated neurocognitive health outcomes. The work of the Center is based on a longitudinal cohort of 800 pregnant African American women who are currently being followed through delivery and designed to examine maternal prenatal stress and its association with the infant microbiome. C-CHEM2 will incorporate a robust assessment of the exposures of the pregnant mother and infant, leveraging substantial resources available from Emory’s NIEHS-funded HERCULES center. Investigators hypothesize that environmental exposure, the microbiome, HPA axis, and immune system together influence neurocognitive and socioemotional development. Type of delivery, genetics, type of feeding, postnatal stress, and maternal-infant interaction are posited as moderators of this intergenerational risk process. Project 1 will focus on the measurement of environmental exposures of the pregnant women and their infants and specifically the association of internal exposures to endocrine-disrupting chemicals in the home environment and their associations with birth outcome. Project 2 will collect infant microbiome, inflammatory marker, and developmental data to examine the association between the prenatal exposures, the infant gut-brain axis, and cognitive/behavioral functioning in the first 18 months of life. Project 3 will use high-resolution metabolomics of the pre- and postnatal samples to test for complex interactions (e.g., exposure x metabolome, microbiome x metabolome, metabolome x HPA axis, immune, neurocognitive and socioemotional measures) that contribute to neurocognitive and socioemotional outcomes. The Community Outreach and Translation Core of C-CHEM2 builds on substantial community engagement already in place in our NIEHS-funded HERCULES center and provides for bi-directional exchange between African American families in Atlanta and scientists. The overall goal is to assess the influence of the environmental exposures of pregnant women on their microbiome and the subsequent impact of the mother’s microbiome on neurodevelopment of the fetus and infant. Achieving this goal would afford a more complete understanding of these effects and consequent ability to translate research strategies to reduce environmental exposures and reduce the prevalence of environmentally-related diseases mitigated by the microbiome.
Journal Articles: 29 Displayed | Download in RIS Format
| Other center views: | All 77 publications | 31 publications in selected types | All 29 journal articles |
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Chang C, Barr D, Zhang Q, Dunlop A, Smarr M, Kannan K, Panuwet P, Tangpricha V, Shi L, Liang D, Corwin E, Ryan P. Associations of single and multiple per-and polyfluoroalkyl substance PFAS exposure with vitamin D biomarkers in African American women during pregnancy. ENVIRONMENTAL RESEARCH 2021;202(111713). |
R836153 (Final) |
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Chang C, Ryan P, Smarr M, Kannan K, Panuwet P, Dunlop A, Corwin E, Barr D. Serum per-and polyfluoroalkyl substance PFAS concentrations and predictors of exposure among pregnant African American women in the Atlanta area, Georgia. ENVIRONMENTAL RESEARCH 2021;198(110445). |
R836153 (Final) |
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Corwin EJ, Hogue CJ, Pearce B, Hill CC, Read TD, Mulle J, Dunlop AL. Protocol for the Emory University African American Vaginal, Oral, and Gut Microbiome in Pregnancy Cohort Study. BMC Pregnancy and Childbirth 2017;17(1):161 (8 pp.). |
R836153 (2018) |
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Eatman J, Dunlop A, Barr D, Corwin E, Hill C, Brennan P, Ryan P, Panuwet P, Taibl K, Tan Y, Liang D, Eik S. Exposure to phthalate metabolites, bisphenol A, and psychosocial stress mixtures and pregnancy outcomes in the Atlanta African American maternal-child cohort. ENVIRONMENTAL RESEARCH 2023;233(116464) |
R836153 (Final) |
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Edwards SM, Cunningham SA, Dunlop AL, Corwin EJ. The maternal gut microbiome during pregnancy. MCN: The American Journal of Maternal/Child Nursing 2017;42(6):310-317. |
R836153 (2018) R836153 (2019) |
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Eick S, Tan Y, Taibl K, Ryan P, Barr D, Huls A, Eatman J, Panuwet P, D'Souza P, Yakimavets V, Lee G, Brennan P, Corwin E, Dunlop A, Liang D. Prenatal exposure to persistent and non-persistent chemical mixtures and associations with adverse birth outcomes in the Atlanta African American Maternal-Child Cohort. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMMIOLOGY 2023;Early Access |
R836153 (Final) |
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Eick S, Barr D, Brennan P, Taibl K, Tan Y, Robinson M, Kannan K, Panuwet P, Yakimavets V, Ryan P, Liang D, Dunlop A. Per-and polyfluoroalkyl substances and psychosocial stressors have a joint effect on adverse pregnancy outcomes in the Atlanta African American Maternal-Child cohort. SCIENCE OF THE TOTAL ENVIRONMENT 2023;857(2):159450. |
R836153 (Final) |
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Frediani JK, Naioti EA, Vos MB, Figueroa J, Marsit CJ, Welsh JA. Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environmental Health 2018;17(1):6 (8 pp.). |
R836153 (2018) R835442 (2018) |
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Gardinassi LG, Xia J, Safo SE, Li S. Bioinformatics tools for the interpretation of metabolomics data. Current Pharmacology Reports 2017;3(6):374-383. |
R836153 (2018) |
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Gardinassi LG, Cordy RJ, Lacerda MVG, Salinas JL, Monteiro WM, Melo GC, Siqueira AM, Val FF, Tran V, Jones DP, Galinski MR, Li S. Metabolome-wide association study of peripheral parasitemia in Plasmodium vivax malaria. International Journal of Medical Microbiology 2017;307(8):533-541. |
R836153 (2018) |
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Kartavenka K, Panuwet P, Yakimavets V, Jaikang C, Thipubon K, D'Souza P, Barr D, Ryan P. LC-MS Quantification of Malondialdehyde-Dansylhydrazine Derivatives in Urine and Serum Samples. JOURNAL OF ANALYTICAL TOXICOLOGY 2020;44(5):470-481. |
R836153 (Final) |
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Li S, Dunlop AL, Jones DP, Corwin EJ. High-resolution metabolomics: review of the field and implications for nursing science and the study of preterm birth. Biological Research for Nursing 2016;18(1):12-22. |
R836153C001 (2016) R836153C003 (2016) R836153C003 (2017) |
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Mutic AD, Baker BJ, McCauley LA. Deleterious effects from occupational exposure to ethylene thiourea in pregnant women. Workplace Health and Safety 2017;65(12):595-602. |
R836153 (2018) |
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Mutic AD, Jordan S, Edwards SM, Ferranti EP, Thul TA, Yang I. The postpartum maternal and newborn microbiomes. MCN: The American Journal of Maternal/Child Nursing 2017;42(6):326-331. |
R836153 (2018) |
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Rodriguez J, Huntington-Moskos L, Johnson A, Williams S, Gulledge E, Feeley C, Rice M. Collecting biological measures for research with children and adolescents. Journal of Pediatric Health Care 2016;30(3):279-283. |
R836153C002 (2016) |
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Rodriguez J, Jordan S, Mutic A, Thul T. The neonatal microbiome: implications for neonatal intensive care unit nurses. MCN: The American Journal of Maternal/Child Nursing 2017;42(6):332-337. |
R836153 (2018) |
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Runkle J, Flocks J, Economos J, Dunlop AL. A systematic review of Mancozeb as a reproductive and developmental hazard. Environment International 2017; 99:29-42. |
R836153 (2018) R836153 (2019) |
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Swales DA, Winiarski DA, Smith AK, Stowe ZN, Newport DJ, Brennan PA. Maternal depression and cortisol in pregnancy predict offspring emotional reactivity in the preschool period. Developmental Psychobiology 2018;60(5):557-566. |
R836153 (2018) |
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Talibl K, Dunlop A, Barr D, Ryan P, Panuwet P, Corwin E, Eatman J, Tan Y, Liang D, Eick S. Phthalate exposure increases interferon-γ during pregnancy: The Atlanta African American Maternal-Child Cohort. SCIENCE OF THE TOTAL ENVIRONMENT 2024;916(170344) |
R836153 (Final) |
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Tan Y, Eick S, Dunlop A, Barr D, Taibl K, Steenland K, Kannan K, Robinson M, Chang C, Panuwet P, Yahimavets V, Marsit C, Ryan P, Liang D. A Prospective Analysis of Per-and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal-Child Cohort. ENVIRONMENTAL HEALH PERSPECTIVES 2024;132(11). |
R836153 (Final) |
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Tchen R, Tan Y, Barr D, Ryan P, Tran V, Li Z, Hu Y, Smith A, Jones D, Dunlop A. Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American women. ENVIRONMENTAL INTERNATIONAL 2022;169(107530). |
R836153 (Final) |
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Yakimavets V, Qiu T, Panuwet P, D'Souza P, Brennan P, Dunlop A, Ryan P, Barr D. Simultaneous quantification of urinary tobacco and marijuana metabolites using solid-supported liquid-liquid extraction coupled with liquid chromatography tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2022;1208(123378). |
R836153 (Final) |
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Zhang Z, Barr D, Dunlop A, Panuwet P, Sarnat J, Lee G, Tan Y, Corwin E, Jones D, Ryan P, Liang D. Assessment of metabolic perturbations associated with exposure to phthalates among pregnant African American women. SCIENCE OF THE TOTAL ENVIRONMENT 2022;818(151689). |
R836153 (Final) |
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Dunlop AL, Knight AK, Satten GA, Cutler AJ, Wright ML, Mitchell RM, Read TD, Mulle J, Hertzberg VS, Hill CC, Smith AK. Stability of the vaginal, oral, and gut microbiota across pregnancy among African American women:the effect of socioeconomic status and antibiotic exposure. PeerJ 2019;7:e8004. |
R836153 (2019) |
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Dunlop AL, Jordan SL, Ferranti EP, Hill CC, Patel S, Hao L, Corwin EJ, Tangpricha V. Total and Free 25-Hydroxy-Vitamin D and Bacterial Vaginosis in Pregnant African American Women. Infectious diseases in obstetrics and gynecology. 2019;2019. |
R836153 (2019) |
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Jordan, S., Baker, B., Dunn, A., Edwards, S., Ferranti, E. Mutic, A., Yang, I., & Rodriguez, J. (2017). Maternal‐child microbiome:Collection, storage, and implications for research and practice. Nursing Research, 66(2), 175‐183. |
R836153 (2017) R836153C002 (2017) |
not available |
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Rodriguez, J., Huntington-Moskos, L., Johnson, A., Williams, S., Gulledge, E., Feeley, C., & Rice, M. (2016). Collecting biological measures for research with children and adolescents. Journal of Pediatric Health Care, Doi 10.1016/j.pedhc.2015.12.007. |
R836153C002 (2017) |
not available |
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Rodriguez, J., Jordan, S., Mutic, A., & Thul, T. The neonatal microbiome:Implications for the NICU nurse. MCN:The American Journal of Maternal/Child Nursing. (in press). |
R836153 (2017) |
not available |
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Mutic, A., Jordan, S., Ferranti, E., Thul, T., Edwards, S., Yang, I. (2017). The Postpartum and Newborn Microbiomes. MCN; The American Journal of Maternal/Child Nursing. (in press). |
R836153 (2017) R836153C002 (2017) |
not available |
Progress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836153C001 Characterizing Exposures and Outcomes in an Urban Birth Cohort (CHERUB)
R836153C002 Microbiome, Environment, and Neurodevelopmental Delay (MEND)
R836153C003 Metabolic, Microbiome and Toxicant-Related Interactions (MATRIX)
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.