Grantee Research Project Results

Role of RSV Infection and Endotoxin in Airway Inflammation

EPA Grant Number: R826711C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R826711
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: HSRC (1989) - Great Plains/Rocky Mountain HSRC
Center Director: Erickson, Larry E.
Title: Role of RSV Infection and Endotoxin in Airway Inflammation
Investigators: Schwartz, David A. , Hunninghake, Gary W.
Current Investigators: Hunninghake, Gary W. , Schwartz, David A.
Institution: University of Iowa
EPA Project Officer: Hahn, Intaek
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

Provision of optimal medical management of childhood asthma in the rural setting is a particular challenge because of limited health care, high rates of poverty, fewer children with health insurance, and unique environmental exposures that are difficult to control. In rural communities, children commonly are exposed to organic dusts, agricultural chemicals, animal allergens, and grain dust mites that are brought into the home on work clothing. Moreover, for children in rural settings, the farm is their home, playground, and workplace, with children as young as five years of age participating in farm chores. There is now convincing evidence that a community-based, multi-component intervention approach is the best route to prevent and control childhood asthma. The overall hypothesis of this study is that environmental intervention is an essential component of an asthma intervention program that must be coordinated with other improvements in health care to reduce the prevalence and severity of asthma among rural children. The goal of this study is therefore to develop, implement, and test a community-based, multi-component model for the prevention of asthma among rural children.

Publications and Presentations:

Publications have been submitted on this subproject: View all 6 publications for this subproject | View all 33 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 6 journal articles for this subproject | View all 32 journal articles for this center

Supplemental Keywords:

children, health, asthma, intervention., RFA, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Children's Health, Atmospheric Sciences, genetic susceptability, Biology, asthma, health effects, rural communities, sensitive populations, endotoxin, airway disease, biological response, respiratory problems, allergic airway, mitogem activated protein kinase, airway inflammation, interleukin, children, interluken, assessment of exposure, childhood respiratory disease, children's vulnerablity, etiology, gene expression, inhalation, human exposure, disease, exposure assessment, genetic susceptibility, agricultural community

Progress and Final Reports:

Main Center Abstract and Reports:

R826711 HSRC (1989) - Great Plains/Rocky Mountain HSRC

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826711C001 Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
R826711C002 Multi-component Intervention Study of Asthma in Children from Rural Communities
R826711C003 Role of RSV Infection and Endotoxin in Airway Inflammation
R826711C004 A Model to Study the Development of Persistent Environmental Airway Disease

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.