Grantee Research Project Results

Physical and Chemical Characteristics of PM in the LAB (Source Receptor Study)

EPA Grant Number: R827352C014
Subproject: this is subproject number 014 , established and managed by the Center Director under grant R827352
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Southern California Children's Environmental Health Center
Center Director: McConnell, Rob Scot
Title: Physical and Chemical Characteristics of PM in the LAB (Source Receptor Study)
Investigators: Sioutas, Constantinos , Hinds, William C. , Cho, Arthur K. , Froines, John R. , Kleinman, Michael T. , Miguel, Antonio , Harkema, Jack
Current Investigators: Sioutas, Constantinos
Institution: University of Southern California , University of California - Los Angeles , Michigan State University , University of California - Irvine
Current Institution: University of Southern California
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The objective of this research project is to focus on the central hypothesis of the Southern California Particle Center and Supersite, which is that organic constituents associated with particulate matter (PM)—including quinones, other organic compounds (polycyclic aromatic hydrocarbons [PAHs], nitro-PAHs, and aldehydes/ketones), and metals—are capable of generating reactive oxygen species and acting as electrophilic agents. They have a central role in allergic airway disease such as asthma and cardiovascular effects through their ability to generate oxidative stress, inflammation, and immunomodulating effects in the lungs and airways.

By taking measurements at three sites, one source and two receptor sites (the receptor sites are locations in which the PM composition has been modified by atmospheric chemistry), we hope to evaluate: (1) the role of atmospheric chemistry in the toxicity of PM and copollutants; and (2) if airway disease and cardiovascular effects are more severe during periods of high photochemical activity (summer) than in periods of low photochemical activity (winter). A mouse and a rat model are being used. The mouse model will be used to test the hypothesis that ambient particles can act as an adjuvant, and will contribute to the development of allergic and asthmatic responses. The rat model tests hypotheses related to the exacerbation of asthma.

Publications and Presentations:

Publications have been submitted on this subproject: View all 66 publications for this subproject | View all 150 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 66 journal articles for this subproject | View all 149 journal articles for this center

Supplemental Keywords:

Particulate matter, quinones, PAHs, aldehydes, ketones, human health risk, asthma, cardiovascular effects, atmospheric chemistry, mobile sources, air toxics, environmental monitoring, photochemical activity, air sampling, California,, RFA, Health, PHYSICAL ASPECTS, Scientific Discipline, Air, Geographic Area, HUMAN HEALTH, particulate matter, Air Pollutants, Environmental Chemistry, State, Risk Assessments, Physical Processes, Health Effects, Biochemistry, children's health, ambient aerosol, asthma, aldehydes, quinones, epidemiology, allergic airway disease, exposure, PAH, air pollution, children, air sampling, aerosol composition, California (CA), allergens, human health risk, aerosols, atmospheric chemistry

Progress and Final Reports:

Main Center Abstract and Reports:

R827352 Southern California Children's Environmental Health Center

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827352C001 The Chemical Toxicology of Particulate Matter
R827352C002 Pro-inflammatory and the Pro-oxidative Effects of Diesel Exhaust Particulate in Vivo and in Vitro
R827352C003 Measurement of the “Effective” Surface Area of Ultrafine and Accumulation Mode PM (Pilot Project)
R827352C004 Effect of Exposure to Freeways with Heavy Diesel Traffic and Gasoline Traffic on Asthma Mouse Model
R827352C005 Effects of Exposure to Fine and Ultrafine Concentrated Ambient Particles near a Heavily Trafficked Freeway in Geriatric Rats (Pilot Project)
R827352C006 Relationship Between Ultrafine Particle Size Distribution and Distance From Highways
R827352C007 Exposure to Vehicular Pollutants and Respiratory Health
R827352C008 Traffic Density and Human Reproductive Health
R827352C009 The Role of Quinones, Aldehydes, Polycyclic Aromatic Hydrocarbons, and other Atmospheric Transformation Products on Chronic Health Effects in Children
R827352C010 Novel Method for Measurement of Acrolein in Aerosols
R827352C011 Off-Line Sampling of Exhaled Nitric Oxide in Respiratory Health Surveys
R827352C012 Controlled Human Exposure Studies with Concentrated PM
R827352C013 Particle Size Distributions of Polycyclic Aromatic Hydrocarbons in the LAB
R827352C014 Physical and Chemical Characteristics of PM in the LAB (Source Receptor Study)
R827352C015 Exposure Assessment and Airshed Modeling Applications in Support of SCPC and CHS Projects
R827352C016 Particle Dosimetry
R827352C017 Conduct Research and Monitoring That Contributes to a Better Understanding of the Measurement, Sources, Size Distribution, Chemical Composition, Physical State, Spatial and Temporal Variability, and Health Effects of Suspended PM in the Los Angeles Basin (LAB)

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.