Grantee Research Project Results

Mechanisms of Particulate-Induced Allergic Asthma

EPA Grant Number: R832139C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R832139
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Mechanisms of Particulate-Induced Allergic Asthma
Investigators: Wills-Karp, Marsha
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The objectives of this research project are to: (1) establish a causal relationship between particulate matter (PM) exposure and asthma morbidity; and (2) determine the mechanisms by which PM elicits these effects.

Publications and Presentations:

Publications have been submitted on this subproject: View all 18 publications for this subproject | View all 117 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 18 journal articles for this subproject | View all 113 journal articles for this center

Supplemental Keywords:

particulate matter, PM, airway hyperresponsiveness, AHR, asthma, complement factor 3, C3, children’s health, Baltimore,, RFA, Scientific Discipline, Health, Air, Geographic Area, HUMAN HEALTH, particulate matter, Health Risk Assessment, State, Health Effects, Allergens/Asthma, asthma, children's health, asthma triggers, air toxics, exposure, air pollution, children, air pollutant, human exposure, airborne pollutants, Maryland (MD), PM, allergens

Progress and Final Reports:

Main Center Abstract and Reports:

R832139 Center for the Study of Childhood Asthma in the Urban Environment

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832139C001 The Epidemiology of Susceptibility to Airborne Particulates and Allergens to Asthma in African Americans
R832139C002 A Randomized Controlled Trial of Behavior Changes in Home Exposure Control
R832139C003 Mechanisms of Particulate-Induced Allergic Asthma
R832139C004 Dendritic Cell Activation by Particulate Matter and Allergen

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.