Grantee Research Project Results

Assessing Maternal and Fetal Exposure to Chemicals

EPA Grant Number: R834678C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R834678
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: Assessing Maternal and Fetal Exposure to Chemicals
Investigators: Woodruff, Tracey J.
Current Investigators: Woodruff, Tracey J. , Stotland, Naomi , Gerona, Roy
Institution: University of California - San Francisco
EPA Project Officer: Hahn, Intaek
Project Period: May 1, 2010 through April 30, 2013
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The ubiquitous exposure to environmental contaminants in the US population, combined with the accumulating evidence of immediate and latent harm caused by in utero exposures, increases the need to better understand exposure to chemicals during key stages of development. For most environmental chemicals, studies that examine exposure prior to birth are scarce. Meanwhile, questions about the degree to which chemicals cross the placenta, accumulate in the fetus and are metabolized remain unanswered. There is a critical need for studies that are designed specifically to answer these questions. In this project we will gather data on chemical exposures during pregnancy, when certain aspects of development are particularly vulnerable to disruption. We will also explore the feasibility and accuracy of using maternal biological monitoring results to predict in utero exposure.

Expected Results:

This data will fill key gaps in our understanding of exposure before birth and capacity to detoxify Bisphenol A (BPA) and could inform and strengthen future studies of the effects of BPA and other environmental chemicals on development.

Publications and Presentations:

Publications have been submitted on this subproject: View all 2 publications for this subproject | View all 73 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 2 journal articles for this subproject | View all 11 journal articles for this center

Supplemental Keywords:

risk assessment, metabolism, bioavailability, ethnic groups, endocrine disruptors, sensitive populations, decision making, measurement methods, RFA, Scientific Discipline, Health, INTERNATIONAL COOPERATION, Biochemistry, Children's Health, Environmental Policy, Biology, prenatal exposure, biological response, chemical mixtures, assessment of exposure, children's vulnerablity, children's environmental health

Progress and Final Reports:

2010

2011

Final Report

Main Center Abstract and Reports:

R834678 Center for Integrative Research on Childhood Leukemia and the Environment - 2015

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834678C001 Assessing Maternal and Fetal Exposure to Chemicals
R834678C002 Assessing the Effects of BPA Exposure on Early Human Development
R834678C003 (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.