Grantee Research Project Results

(Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy

EPA Grant Number: R834678C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R834678
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy
Investigators: Stotland, Naomi
Current Investigators: Stotland, Naomi , Woodruff, Tracey J. , Gerona, Roy
Institution: University of California - San Francisco
EPA Project Officer: Hahn, Intaek
Project Period: May 1, 2010 through April 30, 2013
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

Large national biomonitoring studies are reporting nearly universal exposure to numerous environmental contaminants in the US population, including Bisphenol A (BPA), raising the question of how exactly people are being exposed. Identifying the actual sources of exposure to chemicals that are ubiquitous in our environment is fundamental to the development of strategies and policies that will effectively reduce and prevent harmful exposures. Our understanding of human contact with environmental sources of exposure is inadequately characterized and thus we do not know which sources or behaviors are producing the chemical body burden that we discover through biomonitoring studies. This pilot study is designed to provide research on potential sources of exposure to BPA, to understand more about the biological half-life of BPA and to provide critical insights into potential sources of intrauterine exposure to BPA. To achieve these aims, we will develop and implement a questionnaire on dietary intake of potentially BPA contaminated foods and beverages. We will analyze the relationship between questionnaire data and levels of BPA measured in maternal blood and urine from pregnant women to identify key sources of exposure. We will also explore and account for previously reported relationships between BPA exposure and such socio-demographic factors as age, ethnicity and socio-economic status. We will compare levels of BPA in maternal specimens collected during non-fasting and fasting conditions to characterize the clearance and biological half life of BPA in pregnant women.

Expected Results:

This study addresses data gaps in our knowledge of how humans are exposed to BPA - a key piece of information for reducing and preventing exposures. It will also provide valuable insight regarding the biological half-life of BPA. This information will contribute to efforts toward prevention of exposures and will contribute new tools to future epidemiologic studies.

Publications and Presentations:

Publications have been submitted on this subproject: View all 2 publications for this subproject | View all 73 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 1 journal articles for this subproject | View all 11 journal articles for this center

Supplemental Keywords:

risk assessment, metabolism, bioavailability, ethnic groups, endocrine disruptors, sensitive populations, decision making, measurement methods, RFA, Scientific Discipline, Health, INTERNATIONAL COOPERATION, Biochemistry, Children's Health, Environmental Policy, Biology, prenatal exposure, biological response, developmental toxicity, chemical mixtures, assessment of exposure, children's vulnerablity, children's environmental health

Progress and Final Reports:

2010

2011

Final Report

Main Center Abstract and Reports:

R834678 Center for Integrative Research on Childhood Leukemia and the Environment - 2015

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834678C001 Assessing Maternal and Fetal Exposure to Chemicals
R834678C002 Assessing the Effects of BPA Exposure on Early Human Development
R834678C003 (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.