Grantee Research Project Results
Publications Details for Grant Number EM833367
Atherothrombotic Effects of Particulate Matter
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Abstract | Platelet sensitivity is increased by acrolein | None | Sithu S, Srivastava S, Conklin D, O’Toole TE, Bhatnagar A, D’Souza SE | Sithu S, Srivastava S, Conklin D, O’Toole TE, Bhatnagar A, D’Souza SE. Platelet sensitivity is increased by acrolein. FASEB Journal 2008;22(Meeting Abstract Supplement):897.6. |
EM833367 (Final) |
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| Book Chapter | Aldehydes and cardiovascular disease | COMPREHENSIVE TOXICOLOGY | Conklin DJ, Bhatnagar A | Conklin DJ, Bhatnagar A. Aldehydes and cardiovascular disease. In: McQueen CA, ed. Comprehensive Toxicology. Amsterdam, The Netherlands: Elsevier, 2010, Volume 6, pp. 489-512. |
EM833367 (2008) EM833367 (Final) |
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| Journal Article | The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. | None | Barski OA, Tipparaju SM, Bhatnagar A | Barski OA, Tipparaju SM, Bhatnagar A. The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metabolism Reviews 2008;40(4):553-624. |
EM833367 (Final) |
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| Journal Article | Could dirty air cause diabetes? | None | Bhatnagar A | Bhatnagar A. Could dirty air cause diabetes? Circulation 2009; 119(4):492-494. |
EM833367 (Final) |
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| Journal Article | Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association | None | Brook RD, Rajagopalan S, Pope III CA, Brook JR, Bhatnagar A, Diez-Roux A, Holguin F, Hong Y, Luepker RV, Mittleman M, Peters A, Siscovick D, Smith SC, Kaufman JD | Brook RD, Rajagopalan S, Pope III CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, Whitsel L, Kaufman JD. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 2010;121(21):2331-2378. |
EM833367 (Final) R834797 (2016) R834797C001 (Final) |
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| Journal Article | Protein modification by acrolein: formation and stability of cysteine adducts | None | Cai J, Bhatnagar A, Pierce Jr WM | Cai J, Bhatnagar A, Pierce Jr WM. Protein modification by acrolein: formation and stability of cysteine adducts. Chemical Research in Toxicology 2009;22(4):708-716. |
EM833367 (Final) |
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| Journal Article | Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE-/- mice. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Campen MJ, Lund AK, Knuckles TL, Conklin DJ, Bishop B, Young D, Sielkop SK, Seagrave JC, Reed MD, McDonald JD. | Campen MJ, Lund AK, Knuckles TL, Conklin DJ, Bishop B, Young D, Sielkop SK, Seagrave JC, Reed MD, McDonald JD. Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE-/- mice. Toxicology and Applied Pharmacology 2010;242(3):310-317. |
EM833367 (2009) EM833367 (Final) |
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| Journal Article | Glutathione S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. | None | Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A | Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A. Glutathione S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. American Journal of Physiology Heart and Circulatory Physiology 2009;296(5):H1586-H1597. |
EM833367 (2008) EM833367 (2009) EM833367 (Final) |
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| Journal Article | Increased sensitivity of glutathione-S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity | None | Conklin DJ, Haberzettl P, Lesgards J-F, Prough RA, Srivastava S, Bhatnagar A | Conklin DJ, Haberzettl P, Lesgards J-F, Prough RA, Srivastava S, Bhatnagar A. Increased sensitivity of glutathione-S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity. Journal of Pharmacology and Experimental Therapeutics 2009;331(2):456-469. |
EM833367 (Final) |
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| Journal Article | Acrolein consumption induces systemic dyslipidemia and lipoprotein modification. | None | Conklin DJ, Barski OA, Lesgards JF, Juvan P, Rezen T, Rozman D, Prough RA, Vladykovskaya E, Liu S, Srivastava S, Bhatnagar A | Conklin DJ, Barski OA, Lesgards JF, Juvan P, Rezen T, Rozman D, Prough RA, Vladykovskaya E, Liu S, Srivastava S, Bhatnagar A. Acrolein consumption induces systemic dyslipidemia and lipoprotein modification. Toxicology and Applied Pharmacology 2010;243(1):1-12. |
EM833367 (2008) EM833367 (Final) |
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| Journal Article | Role of endoplasmic reticulum stress in acrolein-induced endothelial activation | None | Haberzettl P, Vladykovskaya E, Srivastava S, Bhatnagar A | Haberzettl P, Vladykovskaya E, Srivastava S, Bhatnagar A. Role of endoplasmic reticulum stress in acrolein-induced endothelial activation. Toxicology and Applied Pharmacology 2009;234(1):14-24. |
EM833367 (2008) EM833367 (2009) EM833367 (Final) |
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| Journal Article | Beyond reactive oxygen species: aldehydes as arbitrators of alarm and adaptation | None | Hill BG, Bhatnagar A | Hill BG, Bhatnagar A. Beyond reactive oxygen species: aldehydes as arbitrators of alarm and adaptation. Circulation Research 2009;105(11):1044-1046. |
EM833367 (Final) |
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| Journal Article | Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-alpha: relevance to hepatitis C. | None | Joshi-Barve S, Amancherla K, Patil M, Bhatnagar A, Mathews S, Gobejishvili L, Cave M, McClain C, Barve S | Joshi-Barve S, Amancherla K, Patil M, Bhatnagar A, Mathews S, Gobejishvili L, Cave M, McClain C, Barve S. Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-alpha: relevance to hepatitis C. Free Radical Biology and Medicine 2009;47(1):47-54. |
EM833367 (Final) |
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| Journal Article | Prenatal exposure to cigarette smoke induces diet- and sex-dependent dyslipidemia and weight gain in adult murine offspring. | None | Ng SP, Conklin DJ, Bhatnagar A, Bolanowski DD, Lyon J, Zelikoff JT | Ng SP, Conklin DJ, Bhatnagar A, Bolanowski DD, Lyon J, Zelikoff JT. Prenatal exposure to cigarette smoke induces diet- and sex-dependent dyslipidemia and weight gain in adult murine offspring. Environmental Health Perspectives 2009;117(7):1042-1048. |
EM833367 (2009) EM833367 (Final) |
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| Journal Article | Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages | None | O'Toole TE, Zheng YT, Hellmann J, Conklin DJ, Barski O, Bhatnagar A | O'Toole TE, Zheng YT, Hellmann J, Conklin DJ, Barski O, Bhatnagar A. Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages. Toxicology and Applied Pharmacology 2009;236(2):194-201. |
EM833367 (2008) EM833367 (2009) EM833367 (Final) |
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| Journal Article | Environmental risk factors for heart disease. | REVIEWS ON ENVIRONMENTAL HEALTH | O’Toole TE, Conklin DJ, Bhatnagar A | O’Toole TE, Conklin DJ, Bhatnagar A. Environmental risk factors for heart disease. Reviews on Environmental Health 2008;23(3):167-202. |
EM833367 (2009) EM833367 (Final) R834514 (2011) R834514 (Final) |
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| Journal Article | Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells | None | O’Toole TE, Hellman J, Wheat L, Haberzettl P, Lee J, Conklin DJ, Bhatnagar A, Pope CA | O’Toole TE, Hellman J, Wheat L, Haberzettl P, Lee J, Conklin DJ, Bhatnagar A, Pope III CA. Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells. Circulation Research 2010;107(2):200-203. |
EM833367 (Final) |
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| Journal Article | Exposure to acrolein by inhalation causes platelet activation | None | Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ, Haberzettl P, O’Toole TE, Bhatnagar A, D’Souza SE | Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ, Haberzettl P, O’Toole TE, Bhatnagar A, D’Souza SE. Exposure to acrolein by inhalation causes platelet activation. Toxicology and Applied Pharmacology 2010;248(2):100-110. |
EM833367 (Final) |
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| Presentation | Role of hepatic lipase in acrolein-induced dyslipidemia in mice. | None | Barski O, Bhatnagar A, Conklin DJ | Barski O, Bhatnagar A, Conklin DJ. Role of hepatic lipase in acrolein-induced dyslipidemia in mice (Abstract 826). Presented at the Society of Toxicology Annual Meeting, Seattle, WA, March 16-20, 2008. |
EM833367 (Final) |
not available |
| Presentation | Effects of acrolein exposure on atherosclerosis in mice: role of dyslipidemia (Abstract 668) | None | Conklin DJ, Srivistava S, Bhatnagar A | Conklin DJ, Srivistava S, Bhatnagar A. Effects of acrolein exposure on atherosclerosis in mice: role of dyslipidemia (Abstract 668). Presented at the Society of Toxicology Annual Meeting, Charlotte, NC, March 25-29, 2007. |
EM833367 (Final) |
not available |
| Presentation | Dyslipidemic and atherosclerotic effects of acrolein exposure (Abstract A56). | None | Conklin DJ, Srivistava S, Bhatnagar A | Conklin DJ, Srivistava S, Bhatnagar A. Dyslipidemic and atherosclerotic effects of acrolein exposure (Abstract A56). Presented at the American Association for the Advancement of Science (AAAS) Annual Meeting, Boston, MA, February 14-18, 2008. |
EM833367 (Final) |
not available |
| Presentation | Endothelial dysfunction and environmental aldehydes: across species comparisons. | None | Conklin DJ | Conklin DJ. Endothelial dysfunction and environmental aldehydes: across species comparisons (Abstract 1257). Presented at the Society of Toxicology Annual Meeting, Seattle, WA, March 16-20, 2008. |
EM833367 (Final) |
not available |
| Presentation | GSTP protects against tobacco smoke-induced endothelial dysfunction | None | Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A | Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A. GSTP protects against tobacco smoke-induced endothelial dysfunction. Presented at the Society of Toxicology Annual Meeting, Baltimore, MD, March 15-19, 2009. |
EM833367 (Final) |
not available |
| Presentation | Effects of prenatal cigarette smoke exposure on lipid parameters associated with offspring cardiac risk: a study in mice (Abstract 2202). | None | Zelikoff JT, Ng SP, Lyon J, Bolanowski D, Conklin D, Bhatnagar A | Zelikoff JT, Ng SP, Lyon J, Bolanowski D, Conklin D, Bhatnagar A. Effects of prenatal cigarette smoke exposure on lipid parameters associated with offspring cardiac risk:a study in mice. Presented at the Society of Toxicology Annual Meeting, Seattle, WA, March 16-20, 2008 (Abstract 2202). |
EM833367 (Final) |
not available |
| Report | Secondhand smoke exposure and cardiovascular effects: making sense of the evidence | None | Goldman LR, Benowitz N, Bhatnagar A, Dominici F, Fienberg S, Friedman GD, Hammond SK, He J, Oparil S, Peterson E, Trapido E | Goldman LR, Benowitz N, Bhatnagar A, Dominici F, Fienberg S, Friedman GD, Hammond SK, He J, Oparil S, Peterson E, Trapido E. Secondhand smoke exposure and cardiovascular effects: making sense of the evidence. Report of the Institute of Medicine. Washington, DC: The National Academies Press, 2010. |
EM833367 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.