Grantee Research Project Results

Genetics of Chlorpyrifos Risk in Minority Populations

EPA Grant Number: R827039C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Genetics of Chlorpyrifos Risk in Minority Populations
Investigators: Wetmur, James G. , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health

Objective:

A molecular genetic research project, closely related to the first three studies, seeks to elucidate the biological mechanisms for individual variation in susceptibility to pesticides. The study will evaluate genotypic and phenotypic heterogeneity in the enzymes that activate and detoxify the oxons of chlorpyrifos and other cholinesterase inhibiting organophosphate pesticides. It will be undertaken using biological samples obtained from the ethnically diverse population of mothers and infants enrolled in the prospective cohort study.

Publications and Presentations:

Publications have been submitted on this subproject: View all 1 publications for this subproject | View all 41 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 1 journal articles for this subproject | View all 33 journal articles for this center

Supplemental Keywords:

infants, exposure, susceptibilty, genetic, enzymes, mechanisms,, RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Toxics, Geographic Area, Health Risk Assessment, Environmental Chemistry, State, pesticides, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Physical Processes, Children's Health, health effects, pesticide exposure, pest management, sensitive populations, community-based intervention, biological response, PCBs, integrated pest management, exposure, children, Human Health Risk Assessment, assessment of exposure, human exposure, pesticide residues, PCB, environmental health hazard, dietary exposure, New York (NY), disease, exposure assessment, developmental toxicants, environmental hazard exposures, community support

Progress and Final Reports:

Main Center Abstract and Reports:

R827039 Center for Research on Early Childhood Exposure and Development in Puerto Rico

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.