Grantee Research Project Results
Final Report: Urban Air Pollution and Persistent Early Life Asthma
EPA Grant Number: R831861C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R831861
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Southern California Children's Environmental Health Center
Center Director: McConnell, Rob Scot
Title: Urban Air Pollution and Persistent Early Life Asthma
Investigators: Gilliland, Frank D.
Institution: University of Southern California
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Hypotheses
- Prevalent asthma with early onset (in the first 5 years of life) is strongly associated with early life traffic within 100 meters of the child’s home.
- Early onset asthma is independently associated with variation of NO, NO2 and ozone within communities, which represent regional products of atmospheric photochemical oxidation of traffic-related pollutants, but which also vary locally with traffic.
- The effects of air pollutants on asthma risk in children are modified by polymorphisms in GSTM1, GSTP1, NQO1, HO-1, and TNFa, genes involved in response to oxidant air pollutants.
Specific Aims:
To assess Hypotheses 1 & 2:
- Identify the population for the proposed case-control study: (a) within the 13 study communities, use existing survey information to identify all kindergarten and first grade children, who have lived in the same residence since before age 2; (b) promote participation through the presentation of the Center video, “A Breath of Air,” by Community Study Liaisons to school nurses, and to parent organizations and interested teachers; and (c) identify all children with asthma that have been active during the previous 12 months (N approximately 160) and a sample of children without asthma, matched on age, sex, race/ethnicity and community.
- Collect information from parents of participants to assess asthma, activity patterns, and risk factors for asthma, using a structured telephone interview, also to be administered by Community Study Liaisons;
- Assess the relationship between traffic within 100 meters of each child’s home and asthma among cases and controls, using information from the Exposure Assessment and Modeling Core;
- Assess the relationship between residential exposure to ambient traffic-related air pollutants and asthma among cases and controls, using information from the Exposure Assessment and Modeling Core; and
- Develop tools for assessment of traffic within 100 meters of homes with COTC Neighborhood Assessment Teams composed of community volunteers selected by community research partners.
To assess Hypothesis 3:
- Genotype cases and controls for polymorphisms in GSTM1, GSTP1, HO-1, NQO1 and TNFa, and assess how these polymorphisms modify the relationship between air pollutants and asthma;
To promote effective communication between partners and to promote broader exchange with the community-based coalitions:
- Assess the burden of asthma-related disease attributable to air pollution in all children living in two communities represented by the community partners, using results from this study and from existing literature;
- Develop a series of community forums with the COTC to discuss the public health burden of air pollution for asthma;
- Integrate new information on air pollution into the environmental action plans developed with families of children with asthma by all community health workers working in service programs of community partners;
- Foster discussion among partners through an active steering committee and through presentation of results at meetings of partner organizations; and
- Participate with the COTC in seminars, community forums and in the critique of policy initiatives by providing the best scientific evidence available on air pollution and childhood asthma.
Summary/Accomplishments (Outputs/Outcomes):
In the last 5 years, we have evaluated three hypotheses about traffic-related air pollution: (1) Prevalent asthma with early onset (in the first 5 years of life) is strongly associated with early life traffic within 100 meters of the child’s home; (2) Early onset asthma is independently associated with variation of NO, NO2 and ozone within communities, which represent regional products of atmospheric photochemical oxidation of traffic related pollutants, but which also vary locally with traffic; (3) The effects of air pollutants on asthma risk in children are modified by polymorphisms in GSTM1, GSTP1, NQO1, HO-1, and TNFa, genes involved in response to oxidant air pollutants.
We found early life asthma that was symptomatic during the year prior to study entry at ages 5-7 was associated with traffic proximity and with NO, NO2 and NOx estimated from dispersion models and traffic volume. There was a dose-response relationship between distance to traffic corridors, with increased risk beginning approximately 200 meters from a major road and increasing approximately linearly with proximity. The odds ratio was 1.6 for asthma within 75 meters of major roads (including freeways, highways and major arterials) where 15% of all participants lived. Risk was larger in children with early life (and longer duration) exposure based on residence at the same address since age 2.
Susceptible groups were identified, including increased risk in girls, consistent with previous literature. Risk of asthma symptoms, severity and prevalence (or asthma incidence in independently funded related work) associated with traffic-related local or regional air pollution was found to be modified by genetic variants involved in oxidative/nitrosative stress pathways, including GSTM1 and P1, TNFa, and EPHX1.
The associations of lifetime asthma with NOx, NO2 and ozone measured in a case-control study were not significant. However, based on these and additional measurements at a total of over 1,000 locations across Southern California improved models predicting spatial surfaces of these pollutants in our study communities based on traffic distance, volume, meteorology, population density, and other nearby land use. Predicted exposure to NOx was associated with asthma and strongly associated with novel wheezy phenotype based on number and severity of symptoms. Regional pollution was not associated with asthma across study communities, after adjusting for local traffic-related exposure, although ozone was found to modify the effect of genetic variants on the risk of asthma and asthmatic bronchitis.
Conclusions:
This study was conducted as a community based participatory research (CBPR) project in close coordination with COTC goals to develop community capacity to understand and apply research results to policy-related prevention. In this context, novel risk assessment methods were developed that identified a several-fold increase in air pollution-related emergency room visits and other severe asthma morbidity likely to result from increased asthma rates due to traffic proximity in the study communities of Long Beach and Riverside. Work with community partners to develop estimates of traffic volume on major traffic corridors has led to novel pilot work by Center investigator Scott Fruin to use these methods to improve our prediction model surfaces.
Journal Articles on this Report : 89 Displayed | Download in RIS Format
| Other subproject views: | All 145 publications | 93 publications in selected types | All 92 journal articles |
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| Other center views: | All 202 publications | 132 publications in selected types | All 131 journal articles |
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Bastain TM, Islam T, Berhane KT, McConnell RS, Rappaport EB, Salam MT, Linn WS, Avol EL, Zhang Y, Gilliland FD. Exhaled nitric oxide, susceptibility and new-onset asthma in the Children’s Health Study. European Respiratory Journal 2011;37(3):523-531. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Berg J, McConnell R, Milam J, Galvan J, Kotlerman J, Thorne P, Jones C, Ferdman R, Eggleston P, Rand C, Lewis MA, Peters J, Richardson J. Rodent allergen in Los Angeles inner city homes of children with asthma. Journal of Urban Health 2008;85(1):52-61. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Berhane K, Gauderman WJ, Stram DO, Thomas DC. Statistical issues in studies of the long-term effects of air pollution: The Southern California Children's Health Study. Statistical Science 2004;19(3):414-449. |
R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Berhane K, Zhang Y, Linn WS, Rappaport EB, Bastain TM, Salam MT, Islam T, Lurmann F, Gilliland FD. The effect of ambient air pollution on exhaled nitric oxide in the Children’s Health Study. European Respiratory Journal 2011;37(5):1029-1036. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Breton CV, Vora H, Salam MT, Islam T, Wenten M, Gauderman WJ, Van den Berg D, Berhane K, Peters JM, Gilliland FD. Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function. American Journal of Respiratory and Critical Care Medicine 2009;179(7):601-607. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Breton CV, Byun HM, Wenten M, Pan F, Yang A, Gilliland FD. Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. American Journal of Respiratory and Critical Care Medicine 2009;180(5):462-467. |
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Breton CV, Salam MT, Vora H, Gauderman WJ, Gilliland FD. Genetic variation in the glutathione synthesis pathway, air pollution, and children’s lung function growth. American Journal of Respiratory and Critical Care Medicine 2011;183(2):243-248. |
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Conti DV, Gauderman WJ. SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data. Genetic Epidemiology 2004;27(4):429-441. |
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Cozen W, Avol E, Diaz-Sanchez D, McConnell R, Gauderman WJ, Cockburn MG, Zadnick J, Jyrala M, Mack TM. Use of an electrostatic dust cloth for self-administered home allergen collection. Twin Research and Human Genetics 2008;11(2):150-155. |
R831861 (Final) R831861C001 (Final) R831861C002 (2007) R831861C002 (Final) R831861C003 (Final) |
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Diaz-Sanchez D, Riedl M. Diesel effects on human health: a question of stress? American Journal of Physiology—Lung Cellular and Molecular Physiology 2005;289(5):L722-L723. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (2006) R831861C002 (Final) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Diaz-Sanchez D, Rumold R, Gong Jr. H. Challenge with environmental tobacco smoke exacerbates allergic airway disease in human beings. Journal of Allergy and Clinical Immunology 2006;118(2):441-446. |
R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (2006) R831861C002 (2007) R831861C002 (Final) R831861C003 (Final) |
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Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J. The effect of air pollution on lung development from 10 to 18 years of age. New England Journal of Medicine 2004;351(11):1057-1067. |
R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2005) R831861C003 (Final) |
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Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 2005;16(6):737-743. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2005) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) R827352 (Final) R827352C007 (Final) R827352C009 (Final) |
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Gauderman WJ, Conti DV. Commentary: Models for longitudinal family data. International Journal of Epidemiology 2005;34(5):1077-1079. |
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Gauderman WJ. Air pollution and children — an unhealthy mix. New England Journal of Medicine 2006;355(1):78-79. |
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Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet 2007;369(9561):571-577. |
R831861 (2005) R831861 (Final) R831861C001 (2007) R831861C001 (Final) R831861C002 (Final) R831861C003 (2007) R831861C003 (Final) R827352 (Final) R827352C007 (Final) |
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Gauderman WJ, Murcray C, Gilliland F, Conti DV. Testing association between disease and multiple SNPs in a candidate gene. Genetic Epidemiology 2007;31(5):383-395. |
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Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363(9403):119-125. |
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Gilliland FD, Li YF, Gong Jr. H, Diaz-Sanchez D. Glutathione s-transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke. American Journal of Respiratory and Critical Care Medicine 2006;174(12):1335-1341. |
R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (2006) R831861C002 (2007) R831861C002 (Final) R831861C003 (2007) R831861C003 (Final) |
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Gilliland FD, Islam T, Berhane K, Gauderman WJ, McConnell R, Avol E, Peters JM. Regular smoking and asthma incidence in adolescents. American Journal of Respiratory and Critical Care Medicine 2006;174(10):1094-1100. |
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Gilliland FD. Outdoor air pollution, genetic susceptibility, and asthma management: opportunities for intervention to reduce the burden of asthma. Pediatrics 2009;123(Suppl 3):S168-S173. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R827027 (2002) R831845 (2005) R832139 (2006) R832141 (2006) R832141 (2007) R832141 (Final) |
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Hricko A. Ships, trucks, and trains: effects of goods movement on environmental health. Environmental Health Perspectives 2006;114(4):A204-A205 (guest editorial). |
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Hricko A. Global trade comes home: community impacts of goods movement. Environmental Health Perspectives 2008;116(2):A78-A81. |
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Islam T, Gauderman WJ, Berhane K, McConnell R, Avol E, Peters JM, Gilliland FD. Relationship between air pollution, lung function and asthma in adolescents. Thorax 2007;62(11):957-963. |
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Islam T, Berhane K, McConnell R, Gauderman WJ, Avol E, Peters JM, Gilliland FD. Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. Thorax 2009;64(3):197-202. |
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Islam T, Breton C, Salam MT, McConnell R, Wenten M, Gauderman WJ, Conti D, Van Den Berg D, Peters JM, Gilliland FD. Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax 2010; 65(2):139-145. |
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Jerrett M, Arain A, Kanaroglou P, Beckerman B, Potoglou D, Sahsuvaroglu T, Morrison J, Giovis C. A review and evaluation of intraurban air pollution exposure models. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(2):185-204. |
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Jerrett M, Shankardass K, Berhane K, Gauderman WJ, Künzli N, Avol E, Gilliland F, Lurmann F, Molitor JN, Molitor JT, Thomas DC, Peters J, McConnell R. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environmental Health Perspectives 2008;116(10):1433-1438. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R835441 (2017) |
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Kanaroglou P, Jerrett M, Morrison J, Beckerman B, Arain A, Gilbert N, Brook J. Establishing an air pollution monitoring network for intra-urban population exposure assessment: a location-allocation approach. Atmospheric Environment 2005;39(13):2399-2409. |
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Kraft P, Yen YC, Stram DO, Morrison J, Gauderman WJ. Exploiting gene-environment interaction to detect genetic associations. Human Heredity 2007;63(2):111-119. |
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Kunzli N, Perez L, Lurmann F, Hricko A, Penfold B, McConnell R. An attributable risk model for exposures assumed to cause both chronic disease and its exacerbations. Epidemiology 2008;19(2):179-185. |
R831861 (Final) R831861C001 (2007) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R827352 (Final) R831845 (2005) |
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Lee YL, Gilliland FD, Wang JY, Lee YC, Guo YL. Associations of FcɛRIβ E237G polymorphism with wheezing in Taiwanese schoolchildren. Clinical & Experimental Allergy 2008;38(3):413-420. |
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Lee YL, McConnell R, Berhane K, Gilliland FD. Ambient ozone modifies the effect of tumor necrosis factor G-308A on bronchitic symptoms among children with asthma. Allergy 2009;64(9):1342-1348. |
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Li Y-F, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005;127(4):1232-1241. |
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Li Y-F, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. Intercellular adhesion molecule-1 and childhood asthma. Human Genetics 2005;117(5):476-484. |
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Li Y-F, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. American Journal of Respiratory and Critical Care Medicine 2006;173(9):970-976. |
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Linn WS, Avila M, Gong H Jr. Exhaled nitric oxide: sources of error in offline measurement. Archives of Environmental Health 2004;59(8):385-391. |
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Linn WS, Rappaport EB, Berhane KT, Bastain TM, Avol EL, Gilliland FD. Exhaled nitric oxide in a population-based study of southern California schoolchildren. Respiratory Research 2009;10(1):28. |
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Linn WS, Berhane KT, Rappaport EB, Bastain TM, Avol EL, Gilliland FD. Relationships of online exhaled, offline exhaled, and ambient nitric oxide in an epidemiologic survey of schoolchildren. Journal of Exposure Science & Environmental Epidemiology 2009;19(7):674-681. |
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Linn WS, Rappaport EB, Berhane KT, Bastain TM, Salam MT, Gilliland FD. Extended exhaled nitric oxide analysis in field surveys of schoolchildren: a pilot test. Pediatric Pulmonology 2009;44(10):1033-1042. |
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McConnell R, Berhane K, Molitor J, Gilliland F, Kunzli N, Thorne PS, Thomas D, Gauderman WJ, Avol E, Lurmann F, Rappaport E, Jerrett M, Peters JM. Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environmental Health Perspectives 2006;114(12):1910-1915. |
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McConnell R, Berhane K, Yao L, Lurmann FW, Avol E, Peters JM. Predicting residential ozone deficits from nearby traffic. Science of the Total Environment 2006;363(1-3):166-174. |
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McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, Kunzli N, Gauderman J, Avol E, Thomas D, Peters J. Traffic, susceptibility, and childhood asthma. Environmental Health Perspectives 2006;114(5):766-772. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (2007) R831861C003 (Final) R826708 (Final) R827352 (Final) R827352C007 (Final) |
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McConnell R, Islam T, Shankardass K, Jerrett M, Lurmann F, Gilliland F, Gauderman J, Avol E, Kunzli N, Yao L, Peters J, Berhane K. Childhood incident asthma and traffic-related air pollution at home and school. Environmental Health Perspectives 2010;118(7):1021-1026. |
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Milam J, McConnell R, Yao L, Berhane K, Jerrett M, Richardson J. Parental stress and childhood wheeze in a prospective cohort study. Journal of Asthma 2008;45(4):319-323. |
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Millstein J, Gilliland F, Berhane K, Gauderman WJ, McConnell R, Avol E, Rappaport EB, Peters JM. Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study. Archives of Environmental Health 2004;59(10):505-514. |
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Millstein J, Siegmund KD, Conti DV, Gauderman WJ. Testing association and linkage using affected-sib-parent study designs. Genetic Epidemiology 2005;29(3):225-233. |
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Millstein J, Conti DV, Gilliland FD, Gauderman WJ. A testing framework for identifying susceptibility genes in the presence of epistasis. American Journal of Human Genetics 2006;78(1):15-27. |
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Mirabelli MC, Kunzli N, Avol E, Gilliland FD, Gauderman WJ, McConnell R, Peters JM. Respiratory symptoms following wildfire smoke exposure: airway size as a susceptibility factor. Epidemiology 2009;20(3):451-459. |
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Molitor J, Molitor N-T, Jerrett M, McConnell R, Gauderman J, Berhane K, Thomas D. Bayesian modeling of air pollution health effects with missing exposure data. American Journal of Epidemiology 2006;164(1):69-76. |
R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R827352 (Final) R831845 (2005) |
Exit Exit |
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Molitor J, Jerrett M, Chang CC, Molitor NT, Gauderman J, Berhane K, McConnell R, Lurmann F, Wu J, Winer A, Thomas D. Assessing uncertainty in spatial exposure models for air pollution health effects assessment. Environmental Health Perspectives 2007;115(8):1147-1153. |
R831861 (Final) R831861C001 (2007) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Mueller-Anneling L, Avol E, Peters JM, Thorne PS. Ambient endotoxin concentrations in PM10 from Southern California. Environmental Health Perspectives 2004;112(5):583-588. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Murcray CE, Lewinger JP, Gauderman WJ. Gene-environment interaction in genome-wide association studies. American Journal of Epidemiology 2009;169(2):219-226. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Perez L, Kunzli N, Avol E, Hricko AM, Lurmann F, Nicholas E, Gilliland F, Peters J, McConnell R. Global goods movement and the local burden of childhood asthma in southern California. American Journal of Public Health 2009;99(Suppl 3):S622-S628. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R831845 (2005) |
Exit |
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Riedl MA, Landaw EM, Saxon A, Diaz-Sanchez D. Initial high-dose nasal allergen exposure prevents allergic sensitization to a neoantigen. Journal of Immunology 2005;174(11):7440-7445. |
R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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Riedl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clinical Immunology 2009;130(3):244-251. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. Journal of Allergy and Clinical Immunology 2005;115(2):221-228. |
R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit Exit |
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Ritz SA, Wan J, Diaz-Sanchez D. Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract. American Journal of Physiology-Lung Cellular and Molecular Physiology 2007;292(1):L33-L39. |
R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (2006) R831861C002 (2007) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Rondeau V, Berhane K, Thomas DC. A three-level model for binary time-series data: the effects of air pollution on school absences in the Southern California Children's Health Study. Statistics in Medicine 2005;24(7):1103-1115. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Ross Z, English PB, Scalf R, Gunier R, Smorodinsky S, Wall S, Jerrett M. Nitrogen dioxide prediction in Southern California using land use regression modeling: potential for environmental health analyses. Journal of Exposure Science and Environmental Epidemiology 2006;16(2):106-114. |
R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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Salam MT, Li Y-F, Langholz B, Gilliland FD. Early-life environmental risk factors for asthma:findings from the Children's Health Study. Environmental Health Perspectives 2004;112(6):760-765. |
R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (2005) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Salam MT, Li Y-F, Langholz B, Gilliland FD. Maternal fish consumption during pregnancy and risk of childhood asthma. Journal of Asthma 2005;42(6):513-518. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit |
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Salam MT, Millstein J, Li YF, Lurmann FW, Margolis HG, Gilliland FD. Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children's Health Study. Environment Health Perspectives 2005;113(11):1638-1644. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
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Salam MT, Margolis HG, McConnell R, McGregor JA, Avol EL, Gilliland FD. Mode of delivery is associated with asthma and allergy occurrences in children. Annals of Epidemiology 2006;16(5):341-346. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
Exit |
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Salam MT, Gauderman WJ, McConnell R, Lin PC, Gilliland FD. Transforming growth factor-β1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. American Journal of Respiratory and Critical Care Medicine 2007;176(12):1192-1199. |
R831861 (Final) R831861C001 (2007) R831861C001 (Final) R831861C002 (Final) R831861C003 (2007) R831861C003 (Final) |
Exit Exit Exit |
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Salam MT, Lin PC, Avol EL, Gauderman WJ, Gilliland FD. Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma. Thorax 2007;62(12):1050-1057. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Salam MT, Islam T, Gilliland FD. Recent evidence for adverse effects of residential proximity to traffic sources on asthma. Current Opinion in Pulmonary Medicine 2008;14(1):3-8. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Salam MT, Islam T, Gauderman WJ, Gilliland FD. Roles of arginase variants, atopy, and ozone in childhood asthma. Journal of Allergy and Clinical Immunology 2009;123(3):596-602. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Salam MT, Bastain TM, Rappaport EB, Islam T, Berhane K, Gauderman WJ, Gilliland FD. Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children. Allergy 2011;66(3):412-419. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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Sawant AA, Cocker III DR, Miller JW, Taliaferro T, Diaz-Sanchez D, Linn WS, Clark KW, Gong Jr. H. Generation and characterization of diesel exhaust in a facility for controlled human exposures. Journal of the Air & Waste Management Association 2008;58(6):829-837. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Saxon A, Diaz-Sanchez D. Air pollution and allergy: you are what you breathe. Nature Immunology 2005;6(3):223-226. |
R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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Shankardass K, McConnell RS, Milam J, Berhane K, Tatalovich Z, Wilson JP, Jerrett M. The association between contextual socioeconomic factors and prevalent asthma in a cohort of Southern California school children. Social Science & Medicine 2007;65(8):1792-1806. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Stram DO. Designs for studies of personal exposure to air pollution and the impact of measurement error. Journal of Toxicology and Environmental Health, Part A 2005;68(13-14):1181-1187. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Stram DO. Software for tag single nucleotide polymorphism selection. Human Genomics 2005;2(2):144-151. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Thomas DC. The need for a systematic approach to complex pathways in molecular epidemiology. Cancer Epidemiology Biomarkers & Prevention 2005;14(3):557-559. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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Thomas DC, Haile RW, Duggan D. Recent developments in genomewide association scans: a workshop summary and review. American Journal of Human Genetics 2005;77(3):337-345. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Thomas DC, Witte JS, Greenland S. Dissecting effects of complex mixtures: who's afraid of informative priors? Epidemiology 2007;18(2):186-190. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Thomas D, Xie R, Gebregziabher M. Two-stage sampling designs for gene association studies. Genetic Epidemiology 2004;27(4):401-414. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Thomas D. Why do estimates of the acute and chronic effects of air pollution on mortality differ? Journal of Toxicology and Environmental Health, Part A 2005;68(13-14):1167-1174. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Thorne PS, Metwali N, Avol E, McConnell RS. Surface sampling for endotoxin assessment using electrostatic wiping cloths. Annals of Occupational Hygiene 2005;49(5):401-406. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit Exit |
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Wan J, Diaz-Sanchez D. Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. Journal of Immunology 2006;177(5):3477-3483. |
R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (2006) R831861C002 (2007) R831861C002 (Final) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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Wan J, Diaz-Sanchez D. Antioxidant enzyme induction: a new protective approach against the adverse effects of diesel exhaust particles. Inhalation Toxicology 2007;19(Suppl 1):177-182. |
R831861 (Final) R831861C001 (Final) R831861C002 (2007) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Wang C, Salam MT, Islam T, Wenten M, Gauderman WJ, Gilliland FD. Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing. Pediatrics 2008;122(1):e107-e114. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. American Journal of Respiratory and Critical Care Medicine 2005;172(12):1563-1568. |
R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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Wenten M, Gauderman WJ, Berhane K, Lin PC, Peters J, Gilliland FD. Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions. American Journal of Epidemiology 2009;170(12):1494-1501. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Wenten M, Li YF, Lin PC, Gauderman WJ, Berhane K, Avol E, Gilliland FD. In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren. Pediatrics 2009;123(5):1344-1351. |
R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Wu J, Lurmann F, Winer A, Lu R, Turco R, Funk T. Development of an individual exposure model for application to the Southern California Children's Health Study. Atmospheric Environment 2005;39(2):259-273. |
R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R827352 (Final) R827352C015 (Final) R828172 (Final) R831845 (2005) |
Exit Exit Exit |
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Wu J, Funk T, Lurmann F, Winer A. Improving spatial accuracy of roadway networks and geocoded addresses. Transactions in GIS 2005;9(4):585-601. |
R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) R827352 (Final) R827352C015 (Final) R831845 (2005) |
Exit |
Supplemental Keywords:
Human health, air, health effects, risk assessment, health risk assessment, human health risk assessment, children's health, biochemistry, environmental chemistry, environmental monitoring, mobile sources, automotive exhaust, engine exhaust, allergen, respiratory problems, children's environmental health, childhood respiratory disease, susceptibility, outreach and education, community-based intervention, airway disease, automotive emissions, ambient particle pollution, asthma, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Air, HUMAN HEALTH, Health Risk Assessment, Environmental Chemistry, Health Effects, Biochemistry, mobile sources, Environmental Monitoring, Children's Health, Risk Assessment, asthma, engine exhaust, traffic, community-based intervention, airway disease, respiratory problems, automotive emissions, Human Health Risk Assessment, automotive exhaust, childhood respiratory disease, susceptibility, ambient particle pollution, children's environmental health, outreach and educationProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R831861 Southern California Children's Environmental Health Center Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831861C001 Urban Air Pollution and Persistent Early Life Asthma
R831861C002 Pollution-Enhanced Allergic Inflammation and Phase II Enzymes
R831861C003 Air Pollution, Exhaled Breath Markers, and Asthma in Susceptible Children
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- 2009
- 2008
- 2007 Progress Report
- 2006 Progress Report
- 2005 Progress Report
- 2004 Progress Report
- Original Abstract
92 journal articles for this subproject
Main Center: R831861
202 publications for this center
131 journal articles for this center