Grantee Research Project Results
2008 Progress Report: Southern Center on Environmentally-Driven Disparities in Birth Outcomes
EPA Grant Number: R833293Center: The Center for Study of Neurodevelopment and Improving Children's Health
Center Director: Murphy, Susan K.
Title: Southern Center on Environmentally-Driven Disparities in Birth Outcomes
Investigators: Miranda , Marie Lynn , Foster, W. Michael , Gelfand, Alan , Ashley-Koch, Allison , Gibson-Davis, Christina , Swamy, Geeta , Reiter, Jerome , Goodall, Jonathan , Tootoo, Joshua , Speer, Marcy , Williams, Redford , Auten, Richard , James, Sherman
Current Investigators: Miranda , Marie Lynn , Ashley-Koch, Allison , Auten, Richard , Foster, W. Michael , Gelfand, Alan , Gibson-Davis, Christina , Goodall, Jonathan , James, Sherman , Reiter, Jerome , Swamy, Geeta , Williams, Redford , Keating, Martha H. , Maxson, Pamela
Institution: Duke University
EPA Project Officer: Callan, Richard
Project Period: May 1, 2007 through April 30, 2012 (Extended to April 30, 2014)
Project Period Covered by this Report: May 1, 2008 through April 30, 2009
Project Amount: $7,735,620
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The Southern Center on Environmentally-Driven Disparities in Birth Outcomes (SCEDDBO) is governed through an Administrative Core that includes an Executive Committee composed of the Director, the two Co-Directors, and the Project Manager; an Internal Steering Committee composed of members of the Executive Committee and the Directors of the Research Projects and the Facility and Community Outreach Cores, as well as a community member and the Director of the Durham County Health Department; and an External Advisory Committee composed of senior environmental health scientists, as well as community representatives, with expertise relevant to SCEDDBO, who provide informal consultation, as well as annual formal evaluation of Center research and outreach activities.
The specific aims of the Administrative Core are to:
- Provide scientific direction and leadership;
- Coordinate and foster interactions among research project and facility core investigators;
- Provide administrative services for the Center;
- Direct the Young Investigators program; and
- Represent Duke’s SCEDDBO to the university, the community, the NIH, other Children’s Environmental Health Centers across the United States, and the policy and scientific community interested in children's environmental health more broadly.
In all activities, SCEDDBO emphasizes the importance of diversity. The decision to focus on health disparities, the gender and racial diversity of Center leadership, the incorporation of natural, social and biomedical scientists, a commitment to community-based participatory research, and efforts to promote the careers of promising new investigators are all indicative of the importance that we place on fostering environments where all people can prosper.
Progress Summary:
Announcement
The Administrative Core (AC) served as the host for Administrator Johnson when he traveled to Durham to announce the SCEDDBO award. AC personnel worked with Nicholas School and Duke University Offices of Communication and Government Relations to ensure that all substantive and organizational requests from the Administrator’s office were fulfilled. A research roundtable allowed SCEDDBO investigators to brief the Administrator on scientific goals and objectives, as well as potential policy applications. The Administrator in turn provided helpful comments on the direction of the center. In addition, a formal event was held on campus, where Administrator Johnson, Stanley Meiburg (EPA), Richard Brodhead (President, Duke University), and Marie Lynn Miranda (PI, SCEDDBO) all offered remarks, followed by Q&A from the audience.
Quality Management Plan
The Administrative Core drafted an initial version of the Quality Management Plan (QMP) that was then distributed to all investigators and staff for critique and comment. Based on this input, the QMP was revised and submitted to the USEPA for approval. Once final approval was received, copies of the QMP were distributed to all persons working on any of the SCEDDBO projects. These individuals then signed the cover sheet thereby agreeing to abide by the policies laid out in the QMP. The Administrative Core keeps a copy of these signed forms in its files.
Leadership Changes
The SCEDDBO research group suffered a tremendous loss when our center co-director, Marcy Speer, died of cancer in August 2007. Richard Auten agreed to take on the role of center co-director. In addition, Jonathan Goodall moved from Duke to the University of South Carolina (USC). We requested that SCEDDBO be allowed to establish a sub-contract with USC, so that Goodall’s work on water quality layers could continue uninterrupted. We also requested that Martha Keating be appointed director of the Community Outreach and Translation Core. All three of these requested changes were approved by the EPA.
Young Investigators Program
In the original plans for SCEDDBO, Marcy Speer was to have mentored both of our Young Investigators. Under our new organizational structure, Rick Auten is mentoring Geeta Swamy, and Sherman James (SCEDDBO’s other center co-director) is mentoring Christina Gibson-Davis.
Year one expenditures
Year one expenditures matched projections in most areas. Spending on travel was higher than anticipated, largely due to rapidly escalating fuel and other travel costs. Salary spending was lower than anticipated due to the unexpected loss of our center co-director, Marcy Speer. Personnel decisions to re-delegate her effort and responsibilities were postponed for a time and those salary dollars went unspent. In addition, other technical and laboratory positions that we would otherwise have filled immediately were delayed as we considered how we wanted to reorganize the center.
IRB Certification
A centralized database on IRB and IUCUAC certification and continuing education requirements is maintained through the AC. Twice a year, Dr. Pamela Maxson, the QA Manager, verifies that all researchers associated with SCEDDBO have completed their basic certification and continuing education (one credit of continuing education is required each year to maintain certification) requirements. Reminders are sent to investigators when they are due for additional training. In addition, Dr. Maxson is responsible for ensuring IRB and IUCAUC Protocols are renewed and updated as necessary. All of these documents are posted to the SCEDDBO internal website, and paper copies are centrally maintained by Dr. Maxson.
IRB Audit
Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes was randomly selected by the Duke School of Medicine Compliance Office, Clinical Trials Quality Assurance Group for internal audit. This process took place from December 2007 through January 2008. The final report was received on January 30, 2008. The AC coordinated the interaction with the auditors. The overall assessment was extremely positive, and Project B staff received additional relevant feedback during the audit process.
Meetings
The Executive Committee meets monthly. We typically schedule these meetings in advance of the Internal Steering Committee meetings in order to set the agenda for the larger group meetings. In addition, in January 2008, the Administrative Core hosted the first meeting of the Science Advisory Committee (SAC). We provided the SAC with documents outlining the basic goals and objective of each center component – as well as overall SCEDDBO goals. Staff associated with each center component also developed a list of questions on which they especially sought the advice and guidance of the SAC. These questions guided much of our discussion and led to a very productive meeting.
Website
The AC provided material on SCEDDBO to the EPA for uploading to the EPA children’s centers website. In addition, we established a site describing SCEDDBO. This site is linked off the website for the Children’s Environmental Health Initiative (http://www.nicholas.duke.edu/cehi Exit ). We also established a secure internal website that allows for discussion boards, email communication, and document storage associated with the work of each of the SCEDDBO components.
Conferences
SCEDDBO PI Miranda and Project Manager Maxson, attended the October 2007 children’s center conference in Washington, D.C., hosted by the EPA. Marie Lynn Miranda presented work on the GIS portal that was developed in support of environmental health needs in the aftermath of Hurricanes Katrina and Rita. Miranda also provided a keynote address on the use of spatial analysis in environmental health research at the EPA-sponsored Sustainability Conference held in Chapel Hill, NC. In addition, in October 2007, Miranda gave the opening plenary address to the International Society for Exposure Assessment. Her talk was entitled “Fostering Environments where All Children Can Prosper.”
Supplement
The AC coordinated the submission of a supplement request to the EPA. If funded, this proposal would allow us to link SHEDS modeling approaches with birth record data that is being used in Research Project A.
Identification of training opportunities
The AC works with all of the other SCEDDBO components to identify key training opportunities for investigators and other research staff. Through this effort, we have developed greater expertise in remotely sensed data, air pollution modeling, centering models of patient care, spatial statistics, and information science.
Journal Articles: 76 Displayed | Download in RIS Format
| Other center views: | All 163 publications | 77 publications in selected types | All 76 journal articles |
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Anthopolos R, James SA, Gelfand AE, Miranda ML. A spatial measure of neighborhood level racial isolation applied to low birthweight, preterm birth, and birthweight in North Carolina. Spatial and Spatio-temporal Epidemiology 2011;2(4):235-246. |
R833293 (2009) R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (2011) R833293C001 (Final) |
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Anthopolos R, Edwards SE, Miranda ML. Effects of maternal prenatal smoking and birth outcomes extending into the normal range on academic performance in fourth grade in North Carolina, USA. Paediatric and Perinatal Epidemiology 2013;27(6):564-574. |
R833293 (2012) R833293 (Final) R833293C001 (Final) |
Exit Exit |
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Anthopolos R, Kaufman JS, Messer LC, Miranda ML. Racial residential segregation and preterm birth: built environment as a mediator. Epidemiology 2014;25(3):397-405. |
R833293 (Final) R833293C001 (Final) |
Exit Exit |
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Auten RL, Potts EN, Mason SN, Fischer B, Huang Y, Foster WM. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. American Journal of Respiratory and Critical Care Medicine 2009;180(12):1218-1226. |
R833293 (Final) |
Exit Exit Exit |
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Auten RL, Foster WM. Biochemical effects of ozone on asthma during postnatal development. Biochimica et Biophysica Acta 2011;1810(11):1114-1119. |
R833293 (2009) R833293 (2010) R833293 (Final) R833293C003 (2010) R833293C003 (Final) |
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Berrocal VJ, Gelfand AE, Holland DM. A bivariate space-time downscaler under space and time misalignment. Annals of Applied Statistics 2010;4(4):1942-1975. |
R833293 (2009) R833293 (Final) R833293C001 (Final) |
Exit Exit Exit |
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Berrocal VJ, Gelfand AE, Holland DM. A spatio-temporal downscaler for output from numerical models. Journal of Agricultural, Biological, and Environmental Statistics 2010;15(2):176-197. |
R833293 (2009) R833293 (Final) R833293C001 (2009) R833293C001 (Final) |
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Berrocal VJ, Gelfand AE, Holland DM, Burke J, Miranda ML. On the use of a PM2.5 exposure simulator to explain birthweight. Environmetrics 2011;22(4):553-571. |
R833293 (2009) R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (2011) R833293C001 (Final) |
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Berrocal VJ, Gelfand AE, Holland DM. Space-time data fusion under error in computer model output: an application to modeling air quality. Biometrics 2012;68(3):837-848. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
Exit Exit |
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Berrocal VJ, Miranda ML, Gelfand AE, Bhattacharya S. Synthesizing categorical datasets to enhance inference. Statistical Methodology 2013;15:25-45. |
R833293 (2007) R833293 (2012) R833293 (Final) R833293C001 (Final) |
Exit Exit |
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Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen J-C, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ. The outdoor air pollution and brain health workshop. NeuroToxicology 2012;33(5):972-984. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C003 (2011) R833293C003 (Final) |
Exit Exit Exit |
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Bolton JL, Smith SH, Huff NC, Gilmour MI, Foster WM, Auten RL, Bilbo SD. Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB Journal 2012;26(11):4743-4754. |
R833293 (2011) R833293 (Final) R833293C003 (2011) R833293C003 (Final) |
Exit Exit Exit |
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Bolton JL, Huff NC, Smith SH, Mason SN, Foster WM, Auten RL, Bilbo SD. Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice. Environmental Health Perspectives 2013;121(9):1075-1082. |
R833293 (2012) R833293 (Final) R833293C003 (Final) |
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Bolton J, Auten R, Bilbo S. Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. BRAIN BEHAVIOR AND IMMUNITY 2014;37:30-44. |
R833293 (Final) |
Exit Exit |
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Brown JS, Graham JA, Chen LC, Postlethwait EM, Ghio AJ, Foster WM, Gordon T. Panel discussion review: session four--assessing biological plausibility of epidemiological findings in air pollution research. Journal of Exposure Science and Environmental Epidemiology 2007;17(Suppl 2):S97-S105. |
R833293 (2007) R833293 (2008) R833293 (Final) R833293C003 (Final) |
Exit Exit |
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Burgette LF, Reiter JP. Multiple imputation for missing data via sequential regression trees. American Journal of Epidemiology 2010;172(9):1070-1076. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C002 (2009) R833293C002 (2010) R833293C002 (Final) |
Exit Exit Exit |
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Burgette LF, Reiter JP, Miranda ML. Exploratory quantile regression with many covariates: an application to adverse birth outcomes. Epidemiology 2011;22(6):859-866. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit |
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Burgette LF, Reiter JP. Nonparametric Bayesian multiple imputation for missing data due to mid-study switching of measurement methods. Journal of the American Statistical Association 2012;107(498):439-449. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Burgette LF, Reiter JP. Modeling adverse birth outcomes via confirmatory factor quantile regression. Biometrics 2012;68(1):92-100. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Buttke DE, Wolkin A, Stapleton HM, Miranda ML. Associations between serum levels of polybrominated diphenyl ether (PBDE) flame retardants and environmental and behavioral factors in pregnant women. Journal of Exposure Science & Environmental Epidemiology 2013;23(2):176-182. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
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Chang HH, Reich BJ, Miranda ML. Chang et al. Respond to “Environmental exposures and preterm birth." American Journal of Epidemiology 2012;175(2):111-112. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Chang HH, Reich BJ, Miranda ML. Time-to-event analysis of fine particle air pollution and preterm birth: results from North Carolina, 2001-2005. American Journal of Epidemiology 2012;175(2):91-98. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) R833863 (2011) |
Exit Exit Exit |
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Chang HH, Reich BJ, Miranda ML. A spatial time-to-event approach for estimating associations between air pollution and preterm birth. Journal of the Royal Statistical Society--Series C (Applied Statistics) 2013;62(2):167-179. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) R834799 (2014) R834799 (2016) R834799 (Final) R834799C002 (2014) R834799C003 (2013) R834799C003 (2014) |
Exit Exit |
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Dadabhoy FZ, Maxson PJ, Huff N, Auten RL. Perinatal exposure to air pollutants had adverse effects on behavioral outcomes in mice. International Journal on Disability and Human Development 2012;11(4):359-368. |
R833293 (Final) R833293C004 (Final) |
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Edwards SE, Strauss B, Miranda ML. Geocoding large population-level administrative datasets at highly resolved spatial scales. Transactions in GIS 2014;18(4):586-603. |
R833293 (Final) R833293C001 (Final) |
Exit |
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Gray SC, Edwards SE, Miranda ML. Assessing exposure metrics for PM and birth weight models. Journal of Exposure Science and Environmental Epidemiology 2010;20(5):469-477. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C001 (2009) R833293C001 (2010) R833293C001 (Final) |
Exit |
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Gray SC, Gelfand AE, Miranda ML. Hierarchical spatial modeling of uncertainty in air pollution and birth weight study. Statistics in Medicine 2011;30(17):2187-2198. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (2011) R833293C001 (Final) |
Exit |
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Gray SC, Edwards SE, Miranda ML. Race, socioeconomic status, and air pollution exposure in North Carolina. Environmental Research 2013;126:152-158. |
R833293 (2012) R833293 (Final) R833293C001 (Final) |
Exit Exit Exit |
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Gray SC, Edwards SE, Schultz BD, Miranda ML. Assessing the impact of race, social factors and air pollution on birth outcomes: a population-based study. Environmental Health 2014;13(1):4. |
R833293 (2012) |
Exit Exit Exit |
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Gregory SG, Anthopolos R, Osgood CE, Grotegut CA, Miranda ML. Association of autism with induced or augmented childbirth in North Carolina Birth Record (1990-1998) and Education Research (1997-2007) databases. JAMA Pediatrics 2013;167(10):959-966. |
R833293 (2012) R833293 (Final) R833293C001 (Final) |
Exit Exit Exit |
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Gruber A, Maxson P. Disparities in psychosocial health and the built environment during pregnancy. International Journal on Disability and Human Development 2012;11(4):377-385. |
R833293 (Final) R833293C004 (Final) |
Exit |
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Heaton MJ, Gray SC, Gelfand AE. Process modeling for contingency tables with ordered categories. Statistical Modelling 2012;12(3):211-228. |
R833293 (Final) R833293C001 (Final) |
Exit |
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Henderson K, Maxson P. Obesity intervention strategies and the built environment in Durham, North Carolina. International Journal of Child and Adolescent Health 2009;2(3):Article 8. |
R833293 (Final) R833293C004 (Final) |
Exit |
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Henry H, Anthopolos R, Maxson P. Traffic-related air pollution and pediatric asthma in Durham County, North Carolina. International Journal on Disability and Human Development 2013;12(4):467-471. |
R833293 (Final) R833293C004 (Final) |
Exit |
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Kim JY, Burnett RT, Neas L, Thurston GD, Schwartz J, Tolbert PE, Brunekreef B, Goldberg MS, Romieu I. Panel discussion review: session two--interpretation of observed associations between multiple ambient air pollutants and health effects in epidemiologic analyses. Journal of Exposure Science and Environmental Epidemiology 2007;17(Suppl 2):S83-S89. |
R833293 (2008) R829213 (Final) |
Exit Exit |
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Koehrn KM, Keating MH. The regulation of agricultural pesticides in North Carolina: implications for migrant farm workers and their families. International Journal of Child and Adolescent Health 2009;2(3):Article 4. |
R833293 (Final) R833293C004 (Final) |
Exit |
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Kroeger GL, Messer L, Edwards SE, Miranda ML. A novel tool for assessing and summarizing the built environment. International Journal of Health Geographics 2012;11:46 (13 pp.). |
R833293 (Final) R833293C004 (Final) |
Exit Exit Exit |
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Lum K, Gelfand AE. Spatial quantile multiple regression using the asymmetric Laplace process. Bayesian Analysis 2012;7(2):235-258. |
R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
Exit Exit |
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Martz M, Anthopolos R, Geller M, Maxson P. Pediatric obesity and food access in Durham, North Carolina. International Journal of Child Health and Human Development 2014;7(3). |
R833293 (Final) R833293C004 (Final) |
Exit Exit |
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Maxson PJ, Edwards SE, Ingram A, Miranda ML. Psychosocial differences between smokers and non-smokers during pregnancy. Addictive Behaviors 2012;37(2):153-159. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Maxson PJ. Together we can break the cycle. International Journal on Disability and Human Development 2012;11(4):307-314. |
R833293 (Final) R833293C004 (Final) |
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Maxson PJ, Edwards SE, Valentiner EM, Miranda ML. A multidimensional approach to characterizing psychosocial health during pregnancy. Maternal and Child Health Journal 2016;20(6):1103-1113. |
R833293 (Final) |
Exit Exit |
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Maxson P, Miranda ML. Pregnancy intention, demographic differences, and psychosocial health. Journal of Women's Health 2011;20(8):1215-1223. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Messer LC, Maxson P, Miranda ML. The urban built environment and associations with women's psychosocial health. Journal of Urban Health 2013;90(5):857-871. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Miranda ML, Keating MH, Edwards SE. Environmental justice implications of reduced reporting requirements for the Toxics Release Inventory Burden Reduction Rule. Environmental Science & Technology 2008;42(15):5407-5414. |
R833293 (Final) R833293C004 (Final) |
Exit Exit Exit |
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Miranda ML, Maxson P, Edwards S. Environmental contributions to disparities in pregnancy outcomes. Epidemiologic Reviews 2009;31(1):67-83. |
R833293 (2008) R833293 (Final) R833293C001 (Final) |
Exit Exit Exit |
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Miranda ML, Edwards SE, Swamy GK, Paul CJ, Neelon B. Blood lead levels among pregnant women: historical versus contemporaneous exposures. International Journal of Environmental Research and Public Health 2010;7(4):1508-1519. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C002 (2009) R833293C002 (2010) R833293C002 (Final) |
Exit Exit |
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Miranda ML, Swamy GK, Edwards S, Maxson P, Gelfand A, James S. Disparities in maternal hypertension and pregnancy outcomes: evidence from North Carolina, 1994-2003. Public Health Reports 2010;125(4):579-587. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C001 (2009) R833293C001 (2010) R833293C001 (Final) |
Exit Exit |
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Miranda ML, Maxson P, Kim D. Early childhood lead exposure and exceptionality designations for students. International Journal of Child Health and Human Development 2010;3(1):77-84. |
R833293 (2008) R833293 (Final) R833293C001 (2009) R833293C001 (Final) |
Exit |
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Miranda ML, Edwards SE, Keating MH, Paul CJ. Making the environmental justice grade: the relative burden of air pollution exposure in the United States. International Journal of Environmental Research and Public Health 2011;8(6):1755-1771. |
R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
Exit Exit Exit |
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Miranda ML, Edwards S, Maxson PJ. Mercury levels in an urban pregnant population in Durham County, North Carolina. International Journal of Environmental Research in Public Health 2011;8(3):698-712. |
R833293 (2010) R833293 (Final) R833293C002 (2010) R833293C002 (Final) |
Exit Exit |
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Miranda ML, Edwards SE. Use of spatial analysis to support environmental health research and practice. North Carolina Medical Journal 2011;72(2):132-135. |
R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
Exit Exit |
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Miranda ML, Edwards SE, Myers ER. Adverse birth outcomes among nulliparous vs. multiparous women. Public Health Reports 2011;126(6):797-805. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (2011) R833293C001 (Final) |
Exit |
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Miranda ML, Anthopolos R, Edwards SE. Seasonality of poor pregnancy outcomes in North Carolina. North Carolina Medical Journal 2011;72(6):447-453. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (2011) R833293C001 (Final) |
Exit Exit Exit |
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Miranda ML, Anthopolos R, Hastings D. A geospatial analysis of the effects of aviation gasoline on childhood blood lead levels. Environmental Health Perspectives 2011;119(10):1513-1516. |
R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
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Miranda ML, Edwards SE, Anthopolos R, Dolinsky DH, Kemper AR. The built environment and childhood obesity in Durham, North Carolina. Clinical Pediatrics 2012;51(8):750-758. |
R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
Exit |
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Miranda ML, Messer LC, Kroeger GL. Associations between the quality of the residential built environment and pregnancy outcomes among women in North Carolina. Environmental Health Perspectives 2012;120(3):471-477. |
R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
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Miranda ML, Edwards SE, Chang HH, Auten RL. Proximity to roadways and pregnancy outcomes. Journal of Exposure Science & Environmental Epidemiology 2013;23(1):32-38. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) R833293C003 (2011) R833293C003 (Final) |
Exit Exit |
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Modlin E, Maxson P. Breaking the cycle of maternal depression: an initiative to improve children’s environmental health. International Journal of Child Health and Human Development 2010;3(4):405-411. |
R833293 (Final) R833293C004 (Final) |
Exit |
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Montagna S, Tokdar ST, Neelon B, Dunson DB. Bayesian latent factor regression for functional and longitudinal data. Biometrics 2012;68(4):1064-1073. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
Exit Exit Exit |
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Neelon B, Swamy GK, Burgette LF, Miranda ML. A Bayesian growth mixture model to examine maternal hypertension and birth outcomes. Statistics in Medicine 2011;30(22):2721-2735. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
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Neelon B, Anthopolos R, Miranda ML. A spatial bivariate probit model for correlated binary data with application to adverse birth outcomes. Statistical Methods in Medical Research 2014;23(2):119-133. |
R833293 (Final) R833293C001 (Final) |
Exit |
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Neelon B, Gelfand AE, Miranda ML. A multivariate spatial mixture model for areal data: examining regional differences in standardized test scores. Journal of the Royal Statistical Societ--Series C (Applied Statistics) 2014;63(5):737-761. |
R833293 (Final) R833293C001 (Final) R833293C002 (Final) |
Exit Exit |
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Ouyang R. The relationship between the built environment and birthweight. Reviews on Environmental Health 2011;26(3):181-186. |
R833293 (Final) R833293C004 (Final) |
Exit |
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Sanders A, Smeester L, Rojas D, DeBussycher T, Wu M, Wright F, Zhou Y-H, Laine J, Rager J, Swamy G, Ashley-Koch A, Miranda ML, Fry R. Cadmium exposure and the epigenome: exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. Epigenetics 2014;9(2):212-221. |
R833293 (Final) R833293C002 (Final) |
Exit Exit |
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Schwartz SL, Gelfand AE, Miranda ML. Joint Bayesian analysis of birthweight and censored gestational age using finite mixture models. Statistics in Medicine 2010;29(16):1710-1723. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C001 (2009) R833293C001 (2010) R833293C001 (Final) R833293C002 (Final) |
Exit Exit |
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Schwartz S, Li F, Reiter JP. Sensitivity analysis for unmeasured confounding in principal stratification settings with binary variables. Statistics in Medicine 2012;31(10):949-962. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Stapleton HM, Eagle S, Anthopolos R, Wolkin A, Miranda ML. Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy. Environmental Health Perspectives 2011;119(10):1454-1459. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
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Swamy GK, Garrett ME, Miranda ML, Ashley-Koch AE. Maternal vitamin D receptor genetic variation contributes to infant birthweight among black mothers. American Journal of Medical Genetics Part A 2011;155A(6):1264-1271. |
R833293 (2009) R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Swamy GK, Edwards S, Gelfand A, James SA, Miranda ML. Maternal age, birth order, and race: differential effects on birthweight. Journal of Epidemiology and Community Health 2012;66(2):136-142. |
R833293 (2009) R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Tassone EC, Miranda ML, Gelfand AE. Disaggregated spatial modelling for areal unit categorical data. Journal of the Royal Statistical Society--Series C (Applied Statistics) 2010;59(1):175-190. |
R833293 (2007) R833293 (2008) R833293 (2009) R833293 (Final) R833293C001 (2009) R833293C001 (Final) |
Exit Exit Exit |
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Vinikoor-Imler LC, Gray SC, Edwards SE, Miranda ML. The effects of exposure to particulate matter and neighbourhood deprivation on gestational hypertension. Paediatric and Perinatal Epidemiology 2012;26(2):91-100. |
R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) |
Exit Exit |
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Zhou X, Reiter JP. A note on Bayesian inference after multiple imputation. The American Statistician 2010;64(2):159-163. |
R833293 (2008) R833293 (2009) R833293 (Final) R833293C002 (2009) R833293C002 (Final) |
Exit Exit |
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Zhu B, Dunson DB, Ashley-Koch AE. Adverse subpopulation regression for multivariate outcomes with high-dimensional predictors. Statistics in Medicine 2012;31(29):4102-4113. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit Exit |
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Zhu B, Ashley-Koch AE, Dunson DB. Generalized admixture mapping for complex traits. G3--Genes, Genomes, Genetics 2013;3(7):1165-1175. |
R833293 (2012) R833293 (Final) R833293C002 (Final) |
Exit Exit Exit |
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Miranda ML, Anthopolos R, Wolkin A, Stapleton HM. Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy. Environment International 2015;85:244-253. |
R833293 (Final) R833293C002 (Final) |
Exit Exit Exit |
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R833293C001 Research Project A: Mapping Disparities in Birth Outcomes
R833293C002 Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
R833293C003 Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
R833293C004 Community Outreach and Translation Core
R833293C005 Geographic Information System and Statistical Analysis Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2012 Progress Report
- 2011 Progress Report
- 2010 Progress Report
- 2009 Progress Report
- 2007 Progress Report
- Original Abstract
76 journal articles for this center