Grantee Research Project Results
Final Report: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
EPA Grant Number: R834799C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R834799
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures
Center Director: Tolbert, Paige
Title: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
Investigators: Sarnat, Jeremy , Winquist, Andrea , Flanders, Dana , Diaz-Sanchez, David , Bergin, Michael , Greenwald, Roby
Institution: Emory University , Georgia Institute of Technology , University of North Carolina at Chapel Hill , Duke University
Current Institution: Emory University , Duke University , Georgia Institute of Technology , University of North Carolina at Chapel Hill
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2016
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
The primary aim of Atlanta Commuters Exposure Study Project 2 (ACE-2) was to examine the effects of exposure to particulate mixtures occurring during automobile commuting and within indoor, non-commuting microenvironments (μE's) and corresponding measures of oxidative stress-mediated response.
Summary/Accomplishments (Outputs/Outcomes):
During the past reporting period, Project 2 investigators continued analyses of data collected as part of the ACE-1 and ACE-2 commuter studies. Seven manuscripts are currently in preparation, to be submitted during the next 6 months. They include an epidemiologic analysis of pulmonary function and systemic inflammatory biomarkers of ACE-2 participants (Golan, et al.), an assessment of the oxidative potential of in-vehicle PM2.5 using measured dithiothreitol (DTT) concentrations (Vreeland, et al.), an analysis of associations between noise and in-vehicle pollution (Ladva, et al.), an analysis of associations between daily and weekly ambient pollution and acute cardiorespiratory response in the pre-commute measurements of ACE-1 and ACE-2 participants (Cornwell, et al.), a metabolomic analysis of asthmatic and non-asthmatic individuals following a ACE-2 commutes (Ladva, et al.), an analysis of salivary cortisol as a biomarker of commuting stress response (Raysoni, et al.), and an epidemiologic analysis of specific on-road sources and acute cardiorespiratory response (Krall, et al.).
Central Project 2 findings include demonstration of clear differences in pollutant levels/composition by commute exposure scenario, and higher levels of DTT in highway commutes as compared to those conducted on a surface street (Figure 1). Figure 1 shows volume-normalized DTT consumption rates for in-vehicle filters collected during 2-hr highway and surface street commutes in Atlanta (light blue and dark blue circles, respectively) and 23-hr roadside data from Fang, et al. (2015) measured in Atlanta during the same time period (red circles).
Conclusions:
Broadly, Project 2 epidemiologic analyses have also provided indication of post-commute response in measured biomarkers consistent with both local and systemic inflammation and autonomic response. Specifically, we have reported in-vehicle pollutant levels to be associated with increase exhaled nitric oxide, C-reactive protein, and breath malondialdehyde, all markers of acute phase inflammatory response; as well as deceased measures of heart rate variability (SDNN) and lung function (FEV1, FVC). We also observed additional evidence of modification by asthma control status. Individuals with poorly-controlled asthma exhibited more pronounced decrements in lung function and increased exhaled nitric oxide, compared to non-asthmatics and individuals with well-controlled asthma.
Journal Articles on this Report : 6 Displayed | Download in RIS Format
| Other subproject views: | All 32 publications | 7 publications in selected types | All 7 journal articles |
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| Other center views: | All 338 publications | 139 publications in selected types | All 135 journal articles |
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Bergin MH, Tripathi SN, Jai Devi J, Gupta T, Mckenzie M, Rana KS, Shafer MM, Villalobos AM, Schauer JJ. The discoloration of the Taj Mahal due to particulate carbon and dust deposition. Environmental Science & Technology 2015;49(2):808-812. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2015) R834799C002 (Final) R835039 (Final) |
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Brown MS, Sarnat SE, DeMuth KA, Brown LAS, Whitlock DR, Brown SW, Tolbert PE, Fitzpatrick AM. Residential proximity to a major roadway is associated with features of asthma control in children. PLoS ONE 2012;7(5):e37044 ( pp.). |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2013) R834799C002 (2014) R834799C002 (2015) R834799C002 (Final) R834799C004 (2012) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Greenwald R, Bergin MH, Yip F, Boehmer T, Kewada P, Shafer MM, Schauer JJ, Sarnat JA. On-roadway in-cabin exposure to particulate matter: measurement results using both continuous and time-integrated sampling approaches. Aerosol Science and Technology 2014;48(6):664-675. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2014) R834799C002 (2015) R834799C002 (Final) |
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Mirabelli MC, Golan R, Greenwald R, Raysoni AU, Holguin F, Kewada P, Winquist A, Flanders WD, Sarnat JA. Modification of traffic-related respiratory response by asthma control in a population of car commuters. Epidemiology 2015;26(4):546-555. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2015) R834799C002 (Final) |
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Sarnat JA, Sarnat SE, Flanders WD, Chang HH, Mulholland J, Baxter L, Isakov V, Ozkaynak H. Spatiotemporally resolved air exchange rate as a modifier of acute air pollution-related morbidity in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):606-615. |
R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2013) R834799C002 (2014) R834799C002 (2015) R834799C002 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Sarnat JA, Golan R, Greenwald R, Raysoni AU, Kewada P, Winquist A, Sarnat SE, Flanders WD, Mirabelli MC, Zora JE, Bergin MH, Yip F. Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Environmental Research 2014;133:66-76. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2014) R834799C002 (2015) R834799C002 (Final) |
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Supplemental Keywords:
health effects, oxidative stress, inflammation, human health, susceptibility, vulnerability, PAHs, PM2.5, organics, elemental carbon, metals, ozone, oxidants, PAH, sulfates, source characterization, mobile sources, Georgia, GA, Scientific Discipline, Health, Health Risk Assessment, Risk Assessments, Environmental Monitoring, Biochemistry, children's health, particulate matter, ambient air monitoring, climate change, automobile exhaust, air pollution, traffic density, airshed modeling, ambient particle health effects, human health riskRelevant Websites:
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834799 The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834799C001 Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS
R834799C002 Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
R834799C003 Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
R834799C004 A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.