Grantee Research Project Results

Associated Project Details for Research Category: Chemical Safety for Sustainability

R826738	In situ Diagnostic Techniques for Probing Solvation Effects in Supercritical Fluid Reaction Media for Synthetic Organic Chemistry	Grant	October 1, 1998 through September 30, 2001
R832734	PON1 as a Predictor of Differential Susceptibility of Children to Organophosphate Pesticides	Grant	March 20, 2006 through February 28, 2009
R833135	Appropriate Serum IgE Testing Strategy, Protocols and Serum Donors	Grant	October 1, 2006 through September 30, 2009
R834065	Differentiating biologically relevant from irrelevant IgE binding to food antigens for improved risk assessment and diagnostic studies using a humanized rat basophil cell line (RBL 30/25)	Grant	May 1, 2009 through March 31, 2011
R834066	Clinically Relevant IgE-Cross-Reactivity of Nut Allergens	Grant	December 1, 2008 through November 30, 2011
R834574	Transatlantic Initiative for Nanotechnology and the Environment	Grant	August 1, 2010 through September 30, 2014
R834575	Consortium for Manufactured Nanomaterial Bioavailability & Environmental Exposure	Grant	August 1, 2010 through August 1, 2013
R834693	Risk Assessment for Manufactured Nanoparticles Used in Consumer Products (RAMNUC)	Grant	April 1, 2011 through June 30, 2014
R834856	Transformation and Fate of Nanomaterials During Wastewater Treatment and Incineration	Grant	August 1, 2010 through August 31, 2013
R834857	Environmental Behavior And Bioavailability Of Ag And Ceo2 Nanoparticles: The Role Of Surface Functionalization and its Interaction with Natural Organic Substances and Iron Oxohydroxides	Grant	August 1, 2010 through July 31, 2014
R834858	Photochemical and Fungal Transformations of Carbon Nanotubes in the Environment	Grant	August 15, 2010 through August 14, 2013
R834859	Uptake of Specific Engineered Nanoparticles (ENP) by Sludge Particulates as Affected by the Presence of Dissolved Organic Matters (DOM)	Grant	February 1, 2011 through January 31, 2014
R834860	Environmental Transformation And Biological Fate Of Fresh And Aged Cerium Oxide Nanoparticles	Grant	March 1, 2011 through June 30, 2013
R834998	Model of Toxicant Response in Engineered Liver	Grant	June 1, 2011 through May 30, 2015
R834999	Predictive QSAR Models of Hepatotoxicity	Grant	June 1, 2011 through May 30, 2015
R835000	A Multi-scale Dose-response Model of AHR Toxicity Pathway Activation in the Human Liver	Grant	June 1, 2011 through May 30, 2015
R835001	Ontologies for Data & Models for Liver Toxicology	Grant	June 1, 2011 through May 30, 2015
R835163	High Information Content Toxicity Screening Using Mouse and Human Stem Cell Models of Endocrine Development and Function	Grant	March 1, 2012 through February 28, 2015
R835164	In Vitro to In Vivo Screening of Thyroid Hormone Receptor Disrupting Chemicals	Grant	March 1, 2012 through February 29, 2016
R835165	Multi-Sensor Reporter Cell Technology to Assess Hazard Involving Endocrine Signaling Pathways	Grant	March 1, 2012 through February 28, 2016
R835166	Carolina Center for Computational Toxicology: Assays, models and tools for NextGen safety assessments	Grant	July 1, 2012 through June 30, 2016
R835167	High-Throughput Cellular Assays for Modeling Toxicity in the Fish Reproductive System	Grant	August 1, 2012 through September 30, 2015
R835168	Toxicity Screening with Zebrafish Assay	Grant	May 1, 2012 through April 30, 2016
R835169	Imaging Assessment of G-protein-coupled Estrogen Receptor Activation	Grant	June 1, 2012 through May 31, 2015
R835170	Cell-Free Neurochemical Screening Assays to Predict Adverse Effects in Mammals, Fish, and Birds	Grant	September 1, 2012 through August 31, 2015
R835541	Establishing an AOP for the Role of the Vitamin D Receptor in Developmental Neurotoxicity	Grant	July 1, 2013 through June 30, 2016
R835550	Identification and Scientific Validation of AOPS Involving Genomic and Nongenomic Intracellular Thyroid Hormone Signaling in Neurodevelopment	Grant	October 1, 2013 through September 30, 2016
R835551	Human Neural Stem Cell Metabolomic, Cellular and Organ Level Adverse Outcome Pathway Relationships for Endocrine Active Compounds	Grant	September 1, 2013 through August 31, 2016
R835552	Human Stem Cell-Based Platform to Predict Selective Developmental Neurotoxicity	Grant	September 1, 2013 through August 31, 2017
R835579	NCCLC: Network for Rapid Assessment of Chemical Life Cycle Impact	Grant	December 1, 2013 through November 30, 2017
R835580	NCCLCs: Life Cycle of Nanomaterials (LCnano)	Grant	March 19, 2014 through March 18, 2018
R835606	Rapid Methods to Estimate Exposure to SVOCs in Indoor Environments	Grant	July 1, 2014 through June 30, 2017
R835612	Toxicogenetics of tetrachloroethylene metabolism and toxicity: Using Collaborative Cross mouse population approach to address remaining gaps in human health assessments	Grant	September 1, 2014 through March 30, 2017
R835641	Tracking Semivolatile Organic Compounds Indoors: Merging Models and Field Sampling to Access Concentrations, Emissions, and Exposures	Grant	September 1, 2014 through August 31, 2017
R835642	Residential Exposure of Young Children to SVOCs	Grant	September 1, 2014 through August 31, 2017
R835643	A Non-Targeted Method for Measuring Multiple Chemical Exposures Amoung a Demographically Diverse Population of Pregnant Women in Northern California	Grant	October 1, 2014 through September 30, 2017
R835644	3-dimensional Micro-gas Chromatography Device for Rapid and Sensitive Indoor Chemical Exposure Analysis	Grant	August 1, 2014 through July 31, 2017
R835736	Vanderbilt - Pittsburgh Resource for Organotypic Models for Predictive Toxicology	Centers	December 1, 2014 through November 30, 2018
R835736C001	Mammosphere Bioreactor For Life-Stage Specific Toxicology	Centers	December 1, 2014 through November 30, 2018
R835736C002	Organotypic Culture Model to Analyze DevelopmentalLimbMalformationsResulting from Toxicant/Teratogen Exposure	Centers	December 1, 2014 through November 30, 2018
R835736C003	Validating a fetal membrane on a chip model for characterizing reproductive toxicant exposure risks	Centers	December 1, 2014 through November 30, 2018
R835736C004	Organotypic Liver Model for Predictive Human Toxicology and Metabolism	Centers	December 1, 2014 through November 30, 2018
R835736C005	Systems Engineering & Analysis for Organotypic Culture Models	Centers	December 1, 2014 through November 30, 2018
R835737	Human Models for Analysis of Pathways (H MAPs) Center	Centers	December 1, 2014 through November 30, 2018
R835737C001	Liver MAPs	Centers	December 1, 2014 through November 30, 2018
R835737C002	Brain MAPs	Centers	December 1, 2014 through November 30, 2018
R835737C003	Cancer MAPs: A 3D Organotypic Microfluidic Culture System to Identify Chemicals that Impact Progression and Development of Breast Cancer	Centers	December 1, 2014 through November 30, 2018
R835737C004	Vascular MAPs: Vascular and Neurovascular Tissue Models	Centers	December 1, 2014 through November 30, 2018
R835737C005	Pathway Analysis Core	Centers	December 1, 2014 through November 30, 2018
R835738	Predictive Toxicology Center for Organotypic Cultures and Assessment ofAOPs for Engineered Nanomaterials	Centers	December 1, 2014 through November 30, 2019
R835738C001	Airway Epithelium Organotypic Culture as a Platform forAdverseOutcomesPathway Assessment of Engineered Nanomaterials	Centers	December 1, 2014 through November 30, 2018
R835738C002	Organotypic Model of Human Kidney as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials	Centers	December 1, 2014 through November 30, 2018
R835738C003	Organotypic Models of Mammalian Liver as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials	Centers	December 1, 2014 through November 30, 2018
R835738C004	Organotypic Model of Testis as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials	Centers	December 1, 2014 through November 30, 2018
R835738C005	Integrating Liver, Kidney and Testis Nanomaterial Toxicity using the Adverse Outcome Pathway Approach	Centers	December 1, 2014 through November 30, 2018
R835795	Integrated Modeling Approaches to Support Systems-Based Ecological Risk Assessment	Grant	June 1, 2015 through May 31, 2017
R835796	System Toxicological Approaches to Define Flame Retardant Adverse Outcome Pathways	Grant	June 1, 2015 through May 31, 2018
R835797	Dynamical Systems Models Based on Energy Budgets for Ecotoxicological Impact Assessment	Grant	June 1, 2015 through May 31, 2018
R835798	Development of a larval fish neurobehavior adverse outcome pathway to predict effects of contaminants at the ecosystem level and across multiple ecologically relevant taxa	Grant	June 1, 2015 through May 31, 2018
R835799	Linking Biological Scales Across Generations: An Estuarine and Marine Model for Measuring The Ecological Impact of Endocrine Disrupting Compounds	Grant	June 1, 2015 through May 31, 2018
R835800	A Bioenergetics-Based Approach to Understanding and Predicting Individual- to Community-Level Ecological Effects of Manufactured Chemicals	Grant	September 1, 2015 through August 31, 2018
R835802	Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and in vitro-to-in vivo Extrapolation for High-throughput Hazard, Dose-response and Variability Assessments	Centers	June 1, 2015 through May 31, 2019
R835802C001	High-throughput Hazard,Dose-responseandPopulationVariabilityAssessmentofCardiotoxicity in aHumanInducedPluripotentStem Cell(iPSC)-derivedinvitro Culture Model	Centers	June 1, 2015 through May 31, 2019
R835802C002	Linking in vitro-to-in vivoToxicity Testing Using Genetically-matchedOrganoids and Mice from a Novel Genetic Reference Population	Centers	June 1, 2015 through May 31, 2019
R835802C003	A Pipeline for in vitro-to-in vivo Extrapolation, Population Modeling, & Prioritization	Centers	June 1, 2015 through May 31, 2019
R839501	Instrumenting phenotypic immunological responses to toxicants that threaten human reproduction	Grant	August 1, 2019 through July 31, 2022
R839502	Skeletal Teratogenicity of Industrial and Environmental Chemicals Predicted with Human Pluripotent Stem Cells in Vitro	Grant	August 1, 2019 through April 28, 2025
R839503	Reducing the reliance on early-life stage testing with relevance to euryhaline fishes: Development and implementation of in-vitro assays predictive of early life stage toxicity and population-level effects in Menidia beryllina	Grant	August 1, 2019 through April 23, 2025
R839504	A Neurovascular Unit on Chip for Reducing Animals in Organophosphate Neurotoxicology	Grant	August 1, 2019 through July 31, 2022
R839505	Multiplexed human BrainSphere Developmental Neurotoxicity Test for Six Key Events of Neural Development	CO-OP	August 1, 2019 through July 31, 2022
R840027	Integrated blood brain barrier computational model development to predict doses of concern for compound linked neurotoxicity	Grant	August 1, 2020 through May 8, 2025
R840029	Toxicokinetic screening of zebrafish cytochrome P450 enzymes for in vitro-in vivo extrapolation	Grant	August 1, 2020 through May 10, 2025
R840031	Measuring Toxicokinetics for Organ-on-Chip Devices	Grant	August 1, 2020 through May 6, 2025
R840032	Integrating tissue chips, rapid untargeted analytical methods and molecular modeling for toxicokinetic screening of chemicals, their metabolites and mixtures	Grant	August 1, 2020 through May 2, 2025
R840033	An in vitro-in silico hybrid approach for high-throughput estimation of trans-barrier permeability for chemical pollutants	Grant	August 1, 2020 through July 30, 2023
R840203	A comprehensive methodology to track genetically recoded organisms and assess their impacts on freshwater microbial communities	Grant	July 1, 2021 through June 30, 2024
R840204	Development of a Data-Driven Model for Assessing Benefits and Risks of the pgSIT Approach for Ae. aegypti Eradication in Hawaii	Grant	July 1, 2021 through May 10, 2025
R840205	Developing Microbial Biocontainment Strategies and Their Assessment Methods	Grant	July 1, 2021 through May 10, 2025
R840206	Microbial Community Models for Measuring Survival and Persistence of SynBio Microbes in Soil	Grant	July 1, 2021 through May 10, 2025
R840207	EcoGenoRisk : Identifying Potential Ecological Risks Posed by a Novel Genome	Grant	July 1, 2021 through April 22, 2025
R840450	A tiered hybrid experimental-computational strategy for rapid risk assessment of complex environmental mixtures using novel analytical and toxicological methods	Grant	September 1, 2022 through May 2, 2025
R840451	Assessment of neurotoxicity of mixtures of PFAS and other neuroactive organic pollutants through integrated in silico, in vitro cellular and in vivo models	Grant	October 1, 2022 through May 12, 2025
R840452	High-Throughput Lung Damage and Inflammation Assessment of Polyaromatic Hydrocarbon Mixtures	Grant	September 1, 2022 through May 9, 2025
R840453	Development of a quantitative adverse outcome pathway (qAOP) network to assess neurodevelopmental toxicity of per- and polyfluoroalkyl substances (PFAs) mixture in C. elegans	Grant	September 1, 2022 through May 13, 2025
R840454	Innovative approach to assess the effect of metal mixtures from infant meconium associated with adverse infant outcomes by identifying methylation loci in mothers and infants	Grant	October 1, 2022 through May 12, 2025
R840455	Whole animal New Approach Methodologies for predicting developmental effects of air pollutant mixtures	Grant	October 1, 2022 through May 9, 2025
R840456	Protein Binding Affinity as the Driver for Studying PFAS Mixture Toxicity	Grant	September 1, 2022 through May 12, 2025
R840457	Oral toxicity assessment of PAH mixtures using an in vitro 3D cell culture bioreactor mimicking the in vivo intestinal tract environment	Grant	September 1, 2022 through May 1, 2025
R840458	Wildfire Smoke Mixtures Toxicity Testing	Grant	October 1, 2022 through May 9, 2025
R840459	Assessment of Underlying Molecular Mechanisms Promoting Adipogenic Outcomes in Complex Mixtures	Grant	September 1, 2022 through May 12, 2025
R840460	Developing an Integrated Framework for Evaluating Toxicity of Real-Life Chemical Mixtures	Grant	October 1, 2022 through May 9, 2025
R840599	Integrated Portable Raman and Electrochemical NanoSystem (I-PRENS) for Neonicotinoid Detection and Remediation in Rural Drinking Water Supplies	Grant	August 1, 2023 through May 8, 2025
R840840	Multimodal Nanosensor for Field Detection and Degradation of PFAS Contamination in Groundwater and Wastewater (SENSE-PFAS)	Grant	August 1, 2024 through April 24, 2025
R841116	Biocompatible Polymer Database from Flavor & Fragrance Molecules	Grant	March 1, 2025 through February 29, 2028
R841117	Discovering Reaction Pathways and Designing Processes for a Sustainable, Circular, and Just Chemical Industry	Grant	March 1, 2025 through April 29, 2025
R841118	High-throughput method development to acquire chemical data needed to inform environmental molecular lifecycles that guide sustainable chemical assessment	Grant	March 1, 2025 through May 1, 2025
R841119	Harnessing Nature: Enzyme Engineering for Polymer Synthesis and Degradation	Grant	March 1, 2025 through February 29, 2028
SU840402	Elimination of microplastics and per- and polyfluoroalkyl substances (PFAS) problems upon the disposal of single-use packaging	Grant	July 1, 2022 through June 30, 2023
SU841133	Development of AI-based software tool for prediction of chemical exposure and toxicity	Grant	March 1, 2025 through February 28, 2027
SV840833	Elimination of Microplastics and Per- and Polyfluoroalkyl Substances (PFAS) Problems Upon the Disposal of Single-Use Packaging	Grant	September 1, 2024 through April 22, 2025

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

Grantee Research Project Results

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