Grantee Research Project Results
Final Report: Center for Child Environmental Health Risks Research
EPA Grant Number: R831709Center: Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials
Center Director: Faustman, Elaine
Title: Center for Child Environmental Health Risks Research
Investigators: Faustman, Elaine , Burbacher, Thomas , Coronado, Gloria , Costa, Lucio G , Fenske, Richard , Furlong, Clement , Griffith, William C. , Karr, Catherine , Thompson, Engelberta , Vigoren, Eric M. , Yost, Michael , Yu, Xiaozhong
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Amount: $3,651,710
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
The theme of the University of Washington’s (UW’s) Center for Child Environmental Health Risks Research (the Center) is: “Working to understand the mechanisms (molecular, genetic, age, exposure and social factors) that define children’s susceptibility to pesticides, identifying the implications of this susceptibility for development and learning, and partnering with our communities to translate our findings into risk communication, risk management and prevention strategies.”
This multi-disciplinary research center has been in place since 1998 and takes advantage of the established landscape of risk research at the University of Washington. The Center is administratively housed within the Institute for Risk Analysis and Risk Communication, also directed by Center Director Dr. Elaine M. Faustman, which is in the UW's School of Public Health. The interdisciplinary nature of the Center allows researchers from various academic backgrounds to work together to reduce the effects of environmental pesticide exposure in children. Research ranges from the basic to the applied, and includes toxicology, exposure assessment, and community intervention. The Center includes partnerships with the Fred Hutchinson Cancer Research Center and the Yakima Valley community, located in the agricultural center of Washington State, to jointly sponsor a Community-Based Participatory Research (CBPR) Project aimed at reducing childhood pesticide exposure.
All Center efforts are highly integrated and comprise two laboratory-based research projects, two field-based research projects, and three facility cores.
The specific objectives of the laboratory-based research projects— a molecular mechanisms research project and a genetic susceptibility research project — are:
- to identify cellular, biochemical and molecular mechanisms that cause adverse developmental neurotoxicity of pesticides; and
- to identify susceptibility factors for developmental neurotoxicity of pesticides
The specific objectives of the two field-based projects — a pesticide exposure pathways research project and the CBPR project — are:
- to improve our understanding of critical pathways of potential pesticide exposure for children; and
- to apply culturally-appropriate interventions to reduce children’s exposure to pesticides
The three facility cores are designed to support the research objectives and to put the research into a child-specific risk assessment context. Thus, the specific objectives of the facility cores are:
- to provide core support for the development and application of risk assessment methods, enabling basic research on pesticide toxicity and exposure to inform risk decisions to protect children’s health from pesticides; and
- to foster partnerships between academic researchers and the community in which information requested by the community and basic research deficiencies/gaps are translated into studies that address the needs of both
Work in the Center is organized around the Public Health paradigm “V-diagram,” which connects occurrence of disease in humans to the original source of the problem. Along the pathway from source/stressor to disease, the diagram identifies intermediate processes (which may be subject to public health intervention) and conditions (which may be observable for public health monitoring and hypothesis testing). This paradigm is central to the overall organization and integration of the various components of the Center. Using Global Positioning System (GPS) tools to relate human activities and land use helps identify how organophosphate (OP) pesticide (stressor) application is transferred/transported to create OP environmental conditions. The CBPR Project focuses on the take-home pathway of OP transfer potentially leading to exposure and resulting dose in children. The biological sampling efforts help identify susceptibility factors and genetic mechanisms relating dose to early biological effect. Biostatistical analyses and outreach link all these components together.
The Public Health paradigm “V-diagram” frames and integrates the Center’s research efforts:
Summary/Accomplishments (Outputs/Outcomes):
Since the Center’s inception in 1998, we have created an infrastructure that integrates data from diverse research studies and translates our findings into improved public health practices and child-protective policies. Here, we provide highlights of Center findings and achievements, and the impacts our activities have had on basic, applied, clinical and public health science, public policy, and the communities that we serve.
Community-Based Participatory Research for Evaluating the Potential for Pesticide Exposures in Farmworker Families
A key feature of the Center is the CBPR Project, which identifies the multiple potential pathways that may contribute to pesticide exposure in adults and children living in agricultural communities. Unlike many other studies of potential pesticide exposure, the CPPR investigators have used a group randomized trial design. Advantages of such an approach are the potential to reach large numbers of people, disseminate messages about behavior across a diverse population, change community norms about behavior, and integrate new behavioral practices into existing community structures and organizations. Part of the study design requires involvement from the communities to guide us in planning intervention activities. The results of this research support the hypothesis that the take-home exposure pathway contributes to residential pesticide contamination in agricultural homes where young children are present.
Highlight: Fostering partnerships with the community in which information requested by the community and basic research deficiencies/gaps are translated into studies that address the needs of both
Identifying Pathways of Pesticide Exposure for Children Living in Farming Communities
Children in farming communities can potentially be exposed to pesticides through multiple routes, and the exposure pathways project has focused on identifying the key routes of potential pesticide exposure. The primary field study has focused on children’s potential exposure to pesticide drift. The study has included micro-environmental and biologic monitoring and successfully identified occupational take-home and community exposures related to spray drift. A novel aspect of this work was the development and use of portable data-logging GPS units to characterize children’s time-location patterns. New statistical models were also developed to combine atmospheric dispersion with time-activity monitoring to estimate potential individual exposure profiles over time. Current work has extended the exposure monitoring and modeling to account for spray drift and volatilization in nearby communities from different spray practices.
Highlight: Characterizing the importance of occupational take-home pathways for preventing and intervening to decrease exposure and protect children’s health
Developing New Methods for Exposure and Risk Assessment
The complex research in which the Center engages often requires innovative methods development. This has included new approaches for characterizing children’s activity patterns using GPS technology and use of laser-based real-time measurement of pesticide spray drift. New mechanistic tools have also been developed including development of transgenic animal models, innovative new in vitro techniques with neuronal precursor cells, and techniques for in vivo mouse neurobehavioral studies. The Center has also developed and adapted innovative statistical methods for the analysis of the complex data sets that are collected in the field studies to better understand the take-home pathway for potential exposure of young children of agricultural workers to OP pesticides in the Yakima Valley of Washington State. These models have relevance not only for Center research but also for general approaches for understanding impacts during early development.
Highlight: Developing novel methods designed to identify and characterize unique aspects of children’s health and development
Understanding the Role of Gene–Environment Interactions for Children’s Susceptibility to Pesticides
Paraoxonase (PON1), a polymorphic enzyme, has been shown to be a major factor in determining susceptibility to the toxicity of certain OP insecticides. Center research has contributed to the success of understanding the role of human plasma PON1 as a risk factor for exposures to diazinon/diazoxon and chlorpyrifos/chlorpyrifos oxon during development and early childhood. Utilizing different approaches, including transgenic animal models, Center researchers have been able to show that PON1 plays even a more important role in young children, as they have a very low level of this enzyme. Because young children are at increased risk, this means that the role of Center work in identifying ways that children can be protected is even more important. Study investigators are also exploring the role of other metabolism enzymes, such as cytochrome P450s.
Highlight: Defining lifestage and gene X exposure (GXE) factors that contribute to children’s susceptibility
Linking Science and Risk Assessment Needs
The Center uses a risk assessment framework to integrate molecular mechanistic research with biomarkers of exposure and genetic susceptibility, test these hypotheses in the field, and directly assess translation via assessment of community and individual interventions. We have established a framework for linked toxicokinetic-toxicodynamic models to address effects on neurodevelopment of exposure to toxic compounds. By addressing both how a substance is distributed, metabolized, and eliminated (toxicokinetics) as well as how the target organ is affected (toxicodynamics) we provide a comprehensive picture of toxicity, one that both summarizes the state of current knowledge and allows for prediction of health risks. We have also built upon a generalized Biologically Based Dose Response (BBDR) model for developmental toxicology that was previously developed by our research group. Model compounds are used to assist us in understanding how to construct BBDR models for neurodevelopment and how to interpret results for potential exposures to OP pesticides as we produce detailed data on neurodevelopmental effects of OPs.
Highlight: Using the risk assessment framework to understand potential for human health impacts
Contributing to Policy Decisions
Research findings from the NIEHS/EPA Children’s Environmental Health Centers have contributed to policy decisions, particularly related to the regulation of pesticides. An excellent example of this input is given by our research on PON1 demonstrating children’s increased sensitivity to OP pesticides contributed to EPA’s decision to remove chlorpyrifos and diazinon from the retail shelves. In September 2006, Dr. Gloria Coronado from the Center was invited to meet with representative from the headquarters of EPA to present information about the health impacts of azinphos-methyl, a pesticide commonly used in apples and pears. Azinphos-methyl has a toxicity ranking of 1, meaning that it is highly toxic. Dr. Coronado presented findings demonstrating that the take-home pathway is a primary pesticide exposure pathway for children. These findings contributed to EPA’s decision to phase-out azinphos-methyl by 2011. Locally, the Pesticide Exposure Pathways Research Project has provided new information on pesticide spray drift. Results from our study were used by the Washington State Department of Agriculture when it considered a new community notification requirement for pesticide applications.
Highlight: Translating science for informing public health decisions
Conclusions:
The highlights above illustrate the Center’s efforts aimed at reducing the adverse effects of environmental pesticide exposures in children. The Center has worked to understand the mechanisms that define children’s susceptibility to pesticides, identify the implications of this susceptibility for development and learning, and partner with our communities to translate our findings into risk communication, risk management, and prevention strategies. Center researchers continue to work in the lab, in the field, and in the community to bring a unique and successful approach to the study of children’s environmental health.
During the life of the Center, we have created an infrastructure that integrates data from diverse research studies and translates our findings into improved public health practices and child-protective policies. Center investigators: 1) share information on methodology and research results within institutions, with other Children’s Environmental Health Centers and the wider scientific research community; 2) have participated in the development of the National Children’s Study (NCS); and 3) joined forces to create the Pacific Northwest Center for the National Children’s Study which has awarded and pending contracts to conduct the NCS in several Pacific Northwest counties. Other activities include: collaborating with our partners to train a new generation of scientists in children’s environmental health sciences; conducting regional, national, and international outreach and translation activities directed to clinicians, public health professionals, and community members; presenting at scientific conferences; and publishing out work. The Center has been a catalyst for growth in building institutional and community capacity to disseminate results relevant to children’s environmental health. The Center has furthermore leveraged considerable funding based on its efforts and successes. In total, over $100 million has been submitted, with $38 million in funding awarded and $25 million pending.
Journal Articles: 133 Displayed | Download in RIS Format
| Other center views: | All 333 publications | 157 publications in selected types | All 133 journal articles |
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Bal-Price AK, Sunol C, Weiss DG, van Vliet E, Westerink RHS, Costa LG . Application of in vitro neurotoxicity testing for regulatory purposes:Symposium III summary and research needs. Neurotoxicology 2008;29(3):520-531. |
R831709 (2007) R831709 (Final) |
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Bartell SM, Ponce RA, Sanga RN, Faustman EM. Human variability in mercury toxicokinetics and steady state biomarker ratios. Environmental Research 2000;84(2):127-132. |
R831709 (2007) |
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Bekris LM, Shephard C, Janer M, Graham J, McNeney B, Shin J, Zarghami M, Griffith W, Farin F, Kavanagh TJ, Lernmark A. Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels. Experimental and Clinical Endocrinology and Diabetes 2007;115(4):221-228. |
R831709 (2005) R831709 (2007) R831709 (Final) R832733 (2007) |
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Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. American Journal of Human Genetics 2001;68(6):1428-1436. |
R831709 (2007) R826886 (2000) R826886C002 (2001) |
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Burry M, Guizzetti M, Oberdoerster J, Costa LG. Developmental neurotoxicity of toluene:in vivo and in vitro effects on astroglial cells. Developmental Neuroscience 2003;25(1):14-19. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Caughlan A, Newhouse K, Namgung U, Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicological Sciences 2004;78(1):125-134. |
R831709 (2007) R831709C001 (2004) |
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Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM, Tward A, Lusis AJ, Jack RM, Costa LG, Furlong CE. Expression of human paraoxonase (PON1) during development. Pharmacogenetics 2003;13(6):357-364. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenetics and Genomics 2005;15(8):589-598. |
R831709 (2005) R831709 (Final) R831709C002 (2005) |
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Cole TB, Jansen K, Park S, Li W-F, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Advances in Experimental Medicine and Biology 2010;660:47-60. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514C004 (Final) |
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Coronado GD, Thompson B, Strong L, Griffith WC, Islas I. Agricultural task and exposure to organophosphate pesticides among farmworkers. Environmental Health Perspectives 2004;112(2):142-147. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2004) |
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Coronado GD, Thompson B, Griffith WC. Children's exposure to OP pesticides:response to Fenske et al. Environmental Health Perspectives 2004;112(15):A866 (correspondence). |
R831709 (2005) R831709C003 (2005) |
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Coronado GD, Thompson B, Griffith WC. Children's exposure to OP pesticides: response to Fenske et al. Environmental Health Perspectives 2004;112(15):A866-A866. |
R831709 (2007) |
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Coronado GD, Thompson B, Strong L, Griffith WC, Islas I. Activities and organophosphate exposures: response. Environmental Health Perspectives 2004;112(13):A725-A726 (correspondence). |
R831709 (2005) R831709 (2007) R831709C003 (2005) |
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Coronado GD, Vigoren EM, Thompson B, Griffith WC, Faustman EM. Organophosphate pesticide exposure and work in pome fruit:evidence for the take-home pesticide pathway. Environmental Health Perspectives 2006;114(7):999-1006. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2006) |
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Coronado GD, Vigoren EM, Griffith WC, Faustman EM, Thompson B. Organophosphate pesticide exposure among pome and non-pome farmworkers:a subgroup analysis of a community randomized trial. Journal of Occupational and Environmental Medicine 2009;51(4):500-509. |
R831709 (2007) R831709 (Final) R832734 (Final) R834514 (2011) R834514 (Final) R834514C001 (Final) |
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Coronado GD, Griffith WC, Vigoren EM, Faustman EM, Thompson B. Where's the dust? Characterizing locations of azinphos-methyl residues in house and vehicle dust among farmworkers with young children. Journal of Occupational and Environmental Hygiene 2010;7(12):663-671. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C001 (Final) |
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Coronado GD, Holte S, Vigoren E, Griffith WC, Faustman E, Thompson B. Organophosphate pesticide exposure and residential proximity to nearby fields:evidence for the drift pathway. Journal of Occupational and Environmental Medicine 2011;53(8):884-891. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C001 (Final) |
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Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) R826886 (2000) R826886C002 (2002) |
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Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine 2003;54:371-392. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) R826886 (2000) R826886C002 (2002) |
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Costa LG, Cole TB, Furlong CE. Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. Clinical Toxicology 2003;41(1):37-45. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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Costa LG, Aschner M, Vitalone A, Syversen T, Soldin OP. Developmental neuropathology of environmental agents. Annual Review of Pharmacology and Toxicology 2004;44:87-110. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Costa LG, Vitalone A, Cole TB, Furlong CE. Modulation of paraoxonase (PON1) activity. Biochemical Pharmacology 2005;69(4):541-550. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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Costa LG, Cole TB, Vitalone A, Furlong CE. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clinica Chimica Acta 2005;352(1-2):37-47. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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Costa LG, Cole TB, Furlong CE. Paraoxonase (PON1): from toxicology to cardiovascular medicine. Acta Biomedica 2005;76(Suppl 2):50-57. |
R831709 (2005) R831709 (Final) |
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Costa LG. Current issues in organophosphate toxicology. Clinica Chimica Acta 2006;366(1-2):1-13. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2006) |
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Costa LG, Cole TB, Furlong CE. Gene-environment interactions:paraoxonase (PON1) and sensitivity to organophosphate toxicity. LabMedicine 2006;37(2):109-113. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2007) R831709C002 (2007) |
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Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Frontiers in Bioscience 2008;13(4):1240-1249. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2007) R831709C002 (2007) |
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Costa LG, Giordano G, Furlong CE. Pharmacological and dietary modulators of paraxonase 1 (PON1) activity and expression: the hunt goes on. Biochemical Pharmacology 2011;81(3):337-344. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
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Cullen AC, Corrales MA, Kramer CB, Faustman EM. The application of genetic information for regulatory standard setting under the clean air act:a decision-analytic approach. Risk Analysis 2008;28(4):877-890. |
R831709 (2007) R831709 (Final) |
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Curl CL, Fenske RA, Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environmental Health Perspectives 2003;111(3):377-382. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W, McLaughlin TJ. A framework for assessing risks to children from exposure to environmental agents. Environmental Health Perspectives 2004;112(2):238-256. |
R831709 (2007) R831709C001 (2004) |
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Drew CH, Grace DA, Silbernagel SM, Hemmings ES, Smith A, Griffith WC, Takaro TK, Faustman EM. Nuclear waste transportation:case studies of identifying stakeholder risk information needs. Environmental Health Perspectives 2003;111(3):263-272. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Critical Reviews in Toxicology 2008;38(Supplement 2):1-125. |
R831709 (2007) R831709 (Final) |
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Elgethun K, Fenske RA, Yost MG, Palcisko GJ. Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. Environmental Health Perspectives 2003;111(1):115-122. |
R831709 (2005) R831709 (2007) R831709 (Final) R826886 (2000) R826886C004 (2002) |
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Elgethun K, Yost MG, Fitzpatrick CTE, Nyerges TL, Fenske RA. Comparison of global positioning system (GPS) tracking and parent-report diaries to characterize children's time-location patterns. Journal of Exposure Science and Environmental Epidemiology 2007;17(2):196-206. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C004 (2006) R831709C004 (2007) |
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Eskenazi B, Harley K, Bradman A, Weltzien E, Jewell NP, Barr DB, Furlong CE, Holland NT. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environmental Health Perspectives 2004;112(10):1116-1124. |
R831709 (2007) R831709 (Final) R831709C002 (2004) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2004) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R831709 (2005) R831709 (Final) R831709C001 (2004) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R829390 (2005) R829390 (Final) R829390C002 (2005) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R832141 (2005) R832141 (2007) R832141 (Final) |
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Faustman EM, Gohlke J, Judd NL, Lewandowski TA, Bartell SM, Griffith WC. Modeling developmental processes in animals:applications in neurodevelopmental toxicology. Environmental Toxicology and Pharmacology 2005;19(3):615-624. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2004) R831709C001 (2005) R831709C001 (2006) |
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Fenske RA, Lu C, Curl CL, Shirai JH, Kissel JC. Biologic monitoring to characterize organophosphorus pesticide exposure among children and workers:an analysis of recent studies in Washington State. Environmental Health Perspectives 2005;113(11):1651-1657. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. |
R831709 (2005) R831709 (2007) R831709 (Final) R827027 (2002) R831710 (2004) R831710 (2005) R831710 (Final) R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R832141 (2006) R832141 (2007) R832141 (Final) |
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Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG. Role of paraoxonase (PON1) status in pesticide sensitivity:genetic and temporal determinants. Neurotoxicology 2005;26(4):651-659. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. Paraoxonase 1 (PON1) status and risk of insecticide exposure. Journal of Biochemical and Molecular Toxicology 2005;19(3):182-183. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2005) |
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Furlong CE, Holland N, Richter RJ, Bradman A, Ho A, Eskenazi B. PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity. Pharmacogenetics and Genomics 2006;16(3):183-190. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C002 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2007) R831710C003 (2006) R831710C003 (2007) |
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Furlong CE. Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds. Journal of Biochemical and Molecular Toxicology 2007;21(4):197-205. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Furlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samii A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP. Human PON1, a biomarker of risk of disease and exposure. Chemico-Biological Interactions 2010;187(1-3):355-361. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) |
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Garry MR, Kavanagh TJ, Faustman EM, Sidhu JS, Liao R, Ware C, Vliet P, Deeb S. Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress. Free Radical Biology and Medicine 2008;44(6):1075-1087. |
R831709 (2005) R831709 (2007) R831709 (Final) |
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Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007;219(2-3):181-189. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2006) R831709C001 (2007) R831709C002 (2007) |
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Giordano G, Pizzurro D, VanDeMark KL, Guizzetti M, Costa LG. Manganese inhibits the ability of astrocytes to promote neuronal differentiation. Toxicology and Applied Pharmacology 2009; 240(2):226-235. |
R831709 (2007) R831709 (Final) |
Exit Exit Exit |
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Gohlke JM, Griffith WC, Faustman EM. The role of cell death during neocortical neurogenesis and synaptogenesis:implications from a computational model for the rat and mouse. Developmental Brain Research 2004;151(1-2):43-54. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
Exit Exit Exit |
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Gohlke JM, Griffith WC, Faustman EM. A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. Toxicological Sciences 2005;86(2):470-484. |
R831709 (2004) R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2005) |
Exit Exit Exit |
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Gohlke JM, Griffith WC, Faustman EM. Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Cerebral Cortex 2007;17(10):2433-2442. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit Exit Exit |
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Gohlke JM, Griffith WC, Faustman EM. Computational models of ethanol-induced neurodevelopmental toxicity across species:implications for risk assessment. Birth Defects Research Part B. Developmental and Reproductive Toxicology 2008;83(1):1-11. |
R831709 (2007) R831709 (Final) |
Exit Exit Exit |
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|
Gribble EJ, Hong SW, Faustman EM. The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53-dependent. Birth Defects Research Part A:Clinical and Molecular Teratology 2005;73(1):29-38. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
Exit |
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Griffith W, Curl CL, Fenske RA, Lu CA, Vigoren EM, Faustman EM. Organophosphate pesticide metabolite levels in pre-school children in an agricultural community:within-and between-child variability in a longitudinal study. Environmental Research 2011;111(6):751-756. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C002 (Final) |
Exit Exit Exit |
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|
Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005;215(3):182-190. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2005) R831709C001 (2006) R831709C002 (2006) |
Exit Exit Exit |
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Guizzetti M, Moore NH, Giordano G, Costa LG. Modulation of neuritogenesis by astrocyte muscarinic receptors. Journal of Biological Chemistry 2008;283(46):31884-31897. |
R831709 (2007) R831709 (Final) |
Exit Exit |
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Guizzetti M, Moore NH, Giordano G, VanDeMark KL, Costa LG. Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia 2010;58(12):1395-1406. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) |
Exit |
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Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. Journal of Biological Chemistry 277(51):49577-49584. |
R831709 (2005) R831709 (2007) |
Exit Exit Exit |
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Hofmann JN, Keifer MC, Furlong CE, De Roos AJ, Farin FM, Fenske RA, van Belle G, Checkoway H. Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environmental Health Perspectives 2009;117(9):1402-1408. |
R831709 (Final) R834514 (2012) R834514 (2013) |
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Hofmann JN, Keifer MC, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occupational and Environmental Medicine 2010;67(6):375-386. |
R831709 (Final) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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|
Holland N, Furlong C, Bastaki M, Richter R, Bradman A, Huen K, Beckman K, Eskenazi B. Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. Environmental Health Perspectives 2006;114(7):985-991. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C002 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2007) R831710C003 (2006) R832734 (2006) R832734 (2007) R832734 (Final) |
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Huen K, Richter R, Furlong C, Eskenazi B, Holland N. Validation of PON1 enzyme activity assays for longitudinal studies. Clinica Chimica Acta 2009;402(1-2):67-74. |
R831709 (2007) R831709 (Final) R831710 (Final) R832734 (2009) R832734 (Final) R834513 (2010) R834513 (2011) R834513 (Final) |
Exit |
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|
Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research:lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2005) R831709C003 (2006) R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391 (Final) R829391C005 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831710C004 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R832139 (2006) |
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Jansen KL, Cole TB, Park SS, Furlong CE, Costa LG. Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds. Toxicology and Applied Pharmacology 2009;236(2):142-153. |
R831709 (Final) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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|
Jarvik GP, Jampsa R, Richter RJ, Carlson CS, Rieder MJ, Nickerson DA, Furlong CE. Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status. Pharmacogenetics 2003;13(5):291-295. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
Exit |
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|
Judd NL, Griffith WC, Takaro T, Faustman EM. A model for optimization of biomarker testing frequency to minimize disease and cost:example of beryllium sensitization testing. Risk Analysis 2003; 23(6):1211-1220. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit |
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|
Judd NL, Karr JR, Griffith WC, Faustman EM. Challenges in defining background levels for human and ecological risk assessments.Human and Ecological Risk Assessment:An International Journal 2003; 9(7):1623-1632. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit |
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|
Judd NL, Griffith WC, Kalman DA, Faustman EM. Assessment of PCB congener analytical methods:do they meet risk assessment needs? Archives of Environmental Contamination and Toxicology 2003; 44(1):132-139. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit Exit |
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|
Judd NL, Griffith WC, Faustman EM. Consideration of cultural and lifestyle factors in defining susceptible populations for environmental disease. Toxicology 2004;198(1-3):121-133. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit Exit Exit |
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|
Judd N, Griffith WC, Faustman EM. Contribution of PCB exposure from fish consumption to total dioxin-like dietary exposure. Regulatory Toxicology and Pharmacology 2004;40(2):125-135. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit Exit Exit |
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|
Kelada SN, Costa-Mallen P, Checkoway H, Viernes HA, Farin FM, Smith-Weller T, Franklin GM, Costa LG, Longstreth Jr WT, Furlong CE, Javrik GP, Swanson PD. Paraoxonase 1 promoter and coding region polymorphisms in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry 2003;74(4):546-547. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
Exit Exit Exit |
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|
Kelada SN, Stapleton PL, Farin FM, Bammler TK, Eaton DL, Smith-Weller T, Franklin GM, Swanson PD, Longstreth Jr WT, Checkoway H. Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease. Neuroscience Letters 2003;337(1):5-8. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit Exit Exit |
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|
Kim JH, Stevens RC, MacCoss MJ, Goodlett DR, Scherl A, Richter RJ, Suzuki SM, Furlong CE. Identification and characterization of biomarkers of organophosphorus exposures in humans. Advances in Experimental Medicine and Biology 2010;660:61-71. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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|
Kissel JC, Curl CL, Kedan G, Lu C, Griffith W, Barr DB, Needham LL, Fenske RA. Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(2):164-171. |
R831709 (2005) R831709 (2007) |
Exit Exit Exit |
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|
Koo B, Gaydos TM, Pandis SN. Evaluation of the equilibrium, dynamic, and hybrid aerosol modeling approaches. Aerosol Science and Technology 2003;37(1):53-64. |
R831709 (2007) R831709C003 (2004) R826371 (Final) R826371C005 (Final) |
Exit Exit |
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|
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, et al. Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height. American Journal of Human Genetics 2011;88(1):6-18. |
R831709 (Final) R834514 (2011) R834514 (Final) |
Exit Exit |
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|
Latowsky G. Report: Community-based, participatory research in Lawrence, Massachusetts, flags environmental health hazards and fuels education and action. Science Communication 2003;25(2):204-208. |
R831709 (2006) R831709 (2007) R828596 (2004) |
Exit |
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|
Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis. Developmental Brain Research 2003;141(1-2):117-128. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
Exit Exit Exit |
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|
Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis:potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
Exit Exit Exit |
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|
Livaudais JC, Thompson B, Islas I, Ibarra G, Anderson J, Coronado GD. Workplace exposures and protective practices of Hispanic warehouse workers. Journal of Immigrant and Minority Health 2009;11(2):122-130. |
R831709 (2007) R831709 (Final) |
Exit |
|
|
Locke E, Coronado GD, Thompson B, Kuniyuki A. Seasonal variation in fruit and vegetable consumption in a rural agricultural community. Journal of the American Dietetic Association 2009;109(1):45-51. |
R831709 (2007) R831709 (Final) |
Exit |
|
|
Luderer U, Diaz D, Faustman EM, Kavanagh TJ. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Molecular Reproduction and Development 2003;65(3):254-261. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit |
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|
Mackenzie-Ross SJ, Brewin CR, Curran HV, Furlong CE, Abraham-Smith KM, Harrison V. Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides. Neurotoxicology and Teratology 2010;32(4):452-459. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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|
Moreira EG, Yu X., Robinson JF, Griffith W, Hong SW, Beyer RP, Bammler TK, Faustman EM. Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos. Toxicology and Applied Pharmacology 2010;245(3):310-325. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
Exit Exit Exit |
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|
Postma J, Karr C, Kieckhefer G. Community health workers and environmental interventions for children with asthma: a systematic review. Journal of Asthma 2009;46(6):564-576. |
R831709 (Final) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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|
Ramaprasad J, Tsai M-Y, Elgethun K, Hebert VR, Felsot A, Yost MG, Fenske RA. The Washington aerial spray drift study: assessment of off-target organophosphorus insecticide atmospheric movement by plant surface volatilization. Atmospheric Environment 2004;38(33):5703-5713. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C004 (2004) |
Exit Exit Exit |
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|
Ramaprasad J, Tsai MG, Fenske RA, Faustman EM, Griffith WC, Felsot AS, Elgethun K, Weppner S, Yost MG. Children's inhalation exposure to methamidophos from sprayed potato fields in Washington State:exploring the use of probabilistic modeling of meteorological data in exposure assessment. Journal of Exposure Science and Environmental Epidemiology 2009;19(6):613-623. |
R831709 (2007) R831709 (Final) R834514 (Final) R834514C002 (Final) |
Exit Exit |
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|
Richter RJ, Jampsa RL, Jarvik GP, Costa LG, Furlong CE. Determination of paraoxonase 1 status and genotypes at specific polymorphic sites. Current Protocols in Toxicology 2004;19(1):4. |
R831709 (2007) R831709 (Final) |
Exit |
|
|
Richter RJ, Jarvik GP, Furlong CE. Determination of paraoxonase (PON1) status without the use of toxic organophosphate substrates. Circulation: Cardiovascular Genetics 2008;1(2):147-152. |
R831709 (2007) R831709 (Final) |
Exit Exit |
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|
Richter RJ, Jarvik GP, Furlong CE. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicology and Applied Pharmacology 2009;235(1):1-9. |
R831709 (2007) R831709 (Final) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit Exit |
|
|
Richter RJ, Jarvik GP, Furlong CE. Paraoxonase 1 (PON1) status as a risk factor for disease or exposure. Advances in Experimental Medicine and Biology 2010;660:29-35. |
R831709 (2007) R831709 (Final) |
|
|
|
Robinson JF, Yu X, Hong S, Griffith WC, Beyer R, Kim E, Faustman EM. Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation. Toxicological Sciences 2009;107(1):206-219. |
R831709 (2007) R831709 (Final) |
Exit Exit |
|
|
Robinson JF, Guerrette Z, Yu X, Hong S, Faustman EM. A systems-based approach to investigate dose-and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation. Birth Defects Research. Part B: Developmental and Reproductive Toxicology 2010;89(3):188-200. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
Exit |
|
|
Robinson JF, Yu X, Hong S, Zhou C, Kim N, DeMasi D, Faustman EM. Embryonic toxicokinetic and dynamic differences underlying strain sensitivity to cadmium during neurulation. Reproductive Toxicology 2010;29(3):279-285. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) |
Exit Exit Exit |
|
|
Robinson JF, Port JA, Yu X, Faustman EM. Integrating genetic and toxicogenomic information for determining underlying susceptibility to developmental disorders. Birth Defects Research. Part A--Clinical and Molecular Teratology 2010;88(10):920-930. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
|
|
Robinson JF, Griffith WC, Yu X, Hong S, Kim E, Faustman EM. Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reproductive Toxicology 2010;30(2):284-291. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
Exit Exit Exit |
|
|
Robinson JF, Yu X, Moreira EG, Hong S, Faustman EM. Arsenic-and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation. Toxicology and Applied Pharmacology 2011;250(2):117-129. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
Exit Exit Exit |
|
|
Schopfer LM, Furlong CE, Lockridge O. Development of diagnostics in the search of an explanation of aerotoxic syndrome. Analytical Biochemistry 2010;404(1):64-74. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
|
|
Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong S-W, Schneider E, Faustman EM. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicological Sciences 2006;89(2):475-484. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2005) R831709C001 (2006) |
Exit Exit Exit |
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|
Snipes SA, Thompson B, O’Connor K, Godina R, Ibarra G. Anthropological and psychological merge:design of a stress measure for Mexican farmworkers. Culture Medicine and Psychiatry 2007;31(3):359-388. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit |
|
|
Stevens RC, Soelberg SD, Eberhart BT, Spencer S, Wekell JC, Chinowsky TM, Trainer VL, Furlong CE. Detection of the toxin domoic acid from clam extracts using a portable surface plasmon resonance biosensor. Harmful Algae 2007;6(2):166-174. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit Exit Exit |
|
|
Stevens RC, Suzuki SM, Cole TB, Park SS, Richter RJ, Furlong CE. Engineered recombinant human paraoxonase 1 (rHUPON1) purified from Escherichia coli protects against organophosphate poisoning. Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12780-12784. |
R831709 (2007) R831709 (Final) |
Exit Exit |
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|
Strong LL, Thompson B, Coronado GD, Griffith WC, Vigoren EM, Islas I. Health symptoms and exposure to organophosphate pesticides in farmworkers. American Journal of Industrial Medicine 2004;46(6):599-606. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2004) |
Exit |
|
|
Strong LL, Thompson B, Koepsell TD, Meischke H. Factors associated with pesticide safety practices in farmworkers. American Journal of Industrial Medicine 2008;51(1):69-81. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C003 (2006) R831709C003 (2007) R832740 (Final) |
Exit Exit |
|
|
Strong LL, Thompson B, Koepsell TD, Meischke H, Coronado GD. Reducing the take-home pathway of pesticide exposure:behavioral outcomes from the Para Niños Saludables study. Journal of Occupational and Environmental Medicine 2009;51(8):922-933. |
R831709 (2007) R831709 (Final) R834514 (Final) R834514C001 (Final) |
Exit |
|
|
Suzuki SM, Stevens RC, Richter RJ, Cole TB, Park S, Otto TC, Cerasoli DM, Lenz DE, Furlong CE. Engineering human PON1 in an E. coli expression system. Advances in Experimental Medicine and Biology 2010;660:37-45. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) |
Exit |
|
|
Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. Journal of Occupational and Environmental Medicine 2003;45(1):42-53. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2004) R826886 (2000) R826886C003 (2002) |
Exit Exit |
|
|
Thompson B, Coronado GD, Vigoren EM, Griffith WC, Fenske RA, Kissel JC, Shirai JH, Faustman EM. Para niños saludables:a community intervention trial to reduce organophosphate pesticide exposure in children of farmworkers.Environmental Health Perspectives 2008;116(5):687-694. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2007) |
|
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Ticozzi N, LeClerc AL, Keagle PJ, Glass JD, Wills AM, van Blitterswijk M, Bosco DA, Rodriguez-Levva I, Gellera C, Ratti A, Taroni F, McKenna-Yasek D, Sapp PC, Silani V, Furlong CE, Brown Jr. RH, Landers JE. Paraoxonase gene mutations in amyotrophic lateral sclerosis. Annals of Neurology 2010;68(1):102-107. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
|
|
Tiffany-Castiglioni E, Venkratraj V, Qian Y. Genetic polymorphisms and mechanisms of neurotoxicity:overview. Neurotoxicology 2005;26(4):641-649. |
R831709 (2007) R831709C002 (2004) |
Exit Exit Exit |
|
|
Tsai M-Y, Elgethun K, Ramaprasad J, Yost MG, Felsot AS, Hebert VR, Fenske RA. The Washington aerial spray drift study: modeling pesticide spray drift deposition from an aerial application. Atmospheric Environment 2005;39(33):6194-6203. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C004 (2005) R831709C004 (2006) |
Exit Exit Exit |
|
|
VanDeMark KL, Guizzetti M, Giordano G, Costa LG. The activation of M1 muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons. Journal of Pharmacology and Experimental Therapeutics 2009;329(2):532-542. |
R831709 (2007) R831709 (Final) |
Exit Exit |
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|
VanDeMark KL, Guizzetti M, Giordano G, Costa LG. Ethanol inhibits muscarinic receptor-induced axonal growth in rat hippocampal neurons. Alcoholism, Clinical and Experimental Research 2009; 33(11):1945-1955. |
R831709 (2007) R831709 (Final) |
Exit |
|
|
Weiner MW, Meyerhoff DJ, Neylan TC, Hlavin J, Ramage ER, McCoy D, Studholme C, Cardenas V, Marmar C, Truran D, Chu PW, Kornak J, Furlong CE, McCarthy C. The relationship between Gulf War war illness, brain N-acetylaspartate, and post-traumatic stress disorder. Military Medicine 2011;176(8):896-902. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
|
|
Weppner S, Elgethun K, Lu C, Herbert V, Yost MG, Fenske RA. The Washington aerial spray drift study:children's exposure to methamidophos in an agricultural community following fixed-wing aircraft applications. Journal of Exposure Science and Environmental Epidemiology 2006;16(5):387-396. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C004 (2006) R831709C004 (2007) |
Exit Exit Exit |
|
|
Wills AM, Landers JE, Zhang H, Richter RJ, Caraganis AJ, Cudkowicz ME, Furlong CE, Brown Jr. RH. Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS. Neurology 2008;70(12):929-934. |
R831709 (2007) R831709 (Final) |
Exit |
|
|
Wong EY, Ponce RA, Farrow S, Bartell SM, Lee RC, Faustman EM. Comparative risk and policy analysis in environmental health. Risk Analysis 2003;23(6):1337-1349. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit |
|
|
Wong EY, Gohlke J, Griffith WC, Farrow S, Faustman EM. Assessing the health benefits of air pollution reduction for children. Environmental Health Perspectives 2004;112(2):226-232. |
R831709 (2005) R831709 (2007) R831709 (Final) |
|
|
|
Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland NT. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. NeuroToxicology 2005;26(2):199-209. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C002 (2004) R831709C002 (2006) R831710 (2004) R831710 (2005) R831710 (Final) |
Exit Exit Exit |
|
|
Yu X, Sidhu JS, Hong S, Faustman EM. Essential role of extracellular matrix (ECM) overlay in establishing the functional integrity of primary neonatal rat Sertoli cell/gonocyte co-cultures:an improved in vitro model for assessment of male reproductive toxicity. Toxicological Sciences 2005;84(2):378-393. |
R831709 (2005) R831709 (2007) R831709 (Final) |
Exit Exit Exit |
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Yu X, Griffith WC, Hanspers K, Dillman III JF, Ong H, Vredevoogd MA, Faustman EM. A system-based approach to interpret dose-and time-dependent microarray data:quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences 2006;92(2):560-577. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2006) R832733 (2007) |
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Yu X, Hong S, Faustman EM. Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures. Toxicological Sciences 2008;104(2):385-396. |
R831709 (2007) R831709 (Final) |
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Yu X, Robinson JF, Gribble E, Hong SW, Sidhu JS, Faustman EM. Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicology and Applied Pharmacology 2008;233(3):389-403. |
R831709 (2007) R831709 (Final) |
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Yu X, Hong S, Moreira EG, Faustman EM. Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity:lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates. Toxicology and Applied Pharmacology 2009;239(3):325-336. |
R831709 (2007) R831709 (Final) |
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Yu X, Robinson JF, Sidhu JS, Hong S, Faustman EM. A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and ethylmercury in mouse embryonic fibroblast. Toxicological Sciences 2010;114(2):356-377. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
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Yu X, Sidhu JS, Hong S, Robinson JF, Ponce RA, Faustman EM. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicological Sciences 2011;120(2):403-412. |
R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Jarvik GP, Hatsukami TS, Carlson C, Richter RJ, Jampsa R, Brophy VH, Margolin S, Rieder M, Nickerson D, Schellenberg GD, Heagerty PJ. Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 2003;23(8):1465-1471. |
R831709 (Final) |
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Zurich MG, Honegger P, Schilter B, Costa LG, Monnet-Tschudi F. Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos. Toxicology and Applied Pharmacology 2004;201(2):97-104. |
R831709 (Final) |
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Costa LG, Guizzetti M, Vitalone A. Diet–brain connections:role of neurotoxicants. Environmental Toxicology and Pharmacology 2005;19(3):395-400. |
R831709 (Final) |
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Judd NL, Drew CH, Acharya C, Mitchell TA, Donatuto JL, Burns GW, Burbacher TM, Faustman EM. Framing scientific analyses for risk management of environmental hazards by communities:case studies with seafood safety issues. Environmental Health Perspectives 2005;113(11):1502-1508. |
R831709 (Final) |
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Ozer EA, Pezzulo A, Shih DM, Chun C, Furlong C, Lusis AJ, Greenberg EP, Zabner J. Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiology Letters 2005;253(1):29-37. |
R831709 (Final) |
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Snipes SA, Thompson B, O'Connor K, Shell-Duncan B, King D, Herrera AP, Navarro B. “Pesticides protect the fruit, but not the people”:using community-based ethnography to understand farmworker pesticide-exposure risks. American Journal of Public Health 2009;99(S3):S616-621. |
R831709 (Final) |
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Louis GB. Principles for evaluating health risks in children associated with exposure to chemicals. World Health Organization; 2006. |
R831709 (Final) |
not available |
Supplemental Keywords:
children’s health, environmental health, pesticide, environmental exposure, risk assessment, risk management, risk communication, community-based participatory research (CBPR), intervention, Washington State, outreach and translation, mechanisms, susceptibility, genetics, gene–interactions, modeling, biostatistics, exposure assessment, exposure pathway, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Environmental Chemistry, Health Risk Assessment, Biochemistry, Children's Health, Risk Assessment, environmental health, health effects, pesticide exposure, community-based intervention, developmental neurotoxicity, biological response, environmental risks, Human Health Risk Assessment, assessment of exposure, children's vulnerablity, genetic polymorphisms, children's environmental healthProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831709C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
R831709C002 Genetic Susceptibility to Pesticides
R831709C003 Community-Based Participatory Research Project
R831709C004 Pesticide Exposure Pathways Research Project
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.