Grantee Research Project Results
Journal Publications Details for Grant Number R834514C004
Genetic Susceptibility
RFA:
Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Asselbergs, F.W., Y. Guo, E.P. van Iperen, S. Sivapalaratnam, V. et al. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet, 2012. 91(5):p. 823-38. |
R834514C004 (Final) R834798C005 (Final) |
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| Journal Article | Cole TB, Jansen K, Park S, Li W-F, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Advances in Experimental Medicine and Biology 2010;660:47-60. |
R831709 (2007) R831709 (Final) R834514 (2011) R834514 (2012) R834514 (2013) R834514C004 (Final) |
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| Journal Article | Cole TB, Fisher JC, Burbacher TM, Costa LG, Furlong CE. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicology and Teratology. 2012;34(3):311-22. |
R834514 (Final) R834514C004 (Final) R834693 (2015) |
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| Journal Article | Giordano G, Tait L, Furlong CE, Cole TB, Kavanagh TJ, Costa LG. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radical Biology and Medicine 2013;58:98-108. |
R834514 (2013) R834514C004 (Final) |
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| Journal Article | Inoue S, Becker AL, Kim J-H, Shu Z, Soelberg SD, Weigel KM, Hiraiwa M, Cairns A, Lee H-B, Furlong CE, Oh K, Lee K-H, Gao D, Chung J-H, Cangelosi GA. Semi-automated, occupationally safe immunofluorescence microtip sensor for rapid detection of mycobacterium cells in sputum. PLoS One 2014;9(1):e86018. |
R834514 (Final) R834514C004 (2015) |
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| Journal Article | Kim DS, Marsillach J, Furlong CE, Jarvik GP. Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease. Pharmacogenomics 2013;14(12):1495-1515. |
R834514 (2013) R834514C004 (Final) |
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| Journal Article | Kim DS, Burt AA, Rosenthal EA, Ranchalis JE, Eintracht JF, Hatsukami TS, Furlong CE, Marcovina S, Albers JJ, Jarvik GP. HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. Journal of the American Heart Association 2014;3(3):e000902. |
R834514 (Final) R834514C004 (2015) |
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| Journal Article | Kim DS, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth Jr. WT, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. Journal of Lipid Research 2014;55(6):1173-1178. |
R834514 (Final) R834514C004 (2015) |
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| Journal Article | Kim DS, Burt AA, Ranchalis JE, Jarvik LE, Eintracht JF, Furlong CE, Jarvik GP. Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants. Nutrition & Metabolism 2014;11(1):44 (9 pp.). |
R834514C004 (2015) |
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| Journal Article | Kim DS, Burt AA, Ranchalis JE, Vuletic S, Vaisar T, Li WF, Rosenthal EA, Dong W, Eintracht JF, Motulsky AG, Brunzell JD, Albers JJ, Furlong CE, Jarvik GP. PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity. Journal of Lipid Research 2015;56(7):1351-1362. |
R834514 (Final) R834514C004 (2015) |
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| Journal Article | Marsillach J, Costa LG, Furlong CE. Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology 2013;307:46-54. |
R834514 (2013) R834514C004 (Final) |
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| Journal Article | Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One 2014;9(10):e110054. |
R834514 (Final) R834514C004 (2015) |
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| Journal Article | Marsillach J, Becker JO, Vaisar T, Hahn BH, Brunzell JD, Furlong CE, deBoer IH, McMahon MA, Hoofnagle AN, DCCT/EDIC Research Group. Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis. Journal of Proteome Research 2015;14(5):2046-2054. |
R834514 (Final) R834514C004 (2015) |
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| Journal Article | Mehta AJ, Zanobetti A, Bind MA, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. Long-term exposure to ambient fine particulate matter and renal function in older men: the Veterans Administration Normative Aging Study. Environmental Health Perspectives 2016;124(9):1353-1360. |
R834514C004 (Final) R834798 (Final) R834798C002 (Final) |
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| Journal Article | Marsillach, J., E.J. Hsieh, R.J. Richter, M.J. Maccoss, and C.E. Furlong, Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact, 2012. |
R834514C004 (Final) |
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| Journal Article | Kim, DS, Crosslin, DR, Auer, PL, Suzuki, SM, Marsillach, J, Burt, AA, Gordon, AS, Meschia, JF, Nalls, MA, Worrall, BB, Longstreth, WT, Jr., Gottesman, RF, Furlong, CE, Peters, U, Rich, SS, Nickerson, DA and Jarvik, GP. 2014. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res. 55(6):1173-1178. 4031948. |
R834514C004 (Final) |
not available |
| Journal Article | Guizzetti, M., N.H. Moore, G. Giordano, K.L. VanDeMark, and L.G. Costa, Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia, 2010. 58(12):p. 1395-406. PMCID2925144. |
R834514C004 (Final) |
not available |
| Journal Article | Richter RJ, Jarvik GP, Furlong CE. 2010. Paraoxonase 1 (PON1) Status as a Risk Factor for Disease or Exposure. Adv Exp Med Biol 660:29-35. PMID 20221868. DOI 10.1007/978-1-60761-350-3_. NIHMSID #193805. |
R834514C004 (Final) |
not available |
| Journal Article | Kim, DS, Burt, AA, Ranchalis, JE, Richter, RJ, Marshall, JK, Nakayama, KS, Jarvik, ER, Eintracht, JF, Rosenthal, EA, Furlong, CE and Jarvik, GP. 2012. Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res. 53(11):2450-8. PMCID:PMC3466014. |
R834514C004 (Final) |
not available |
| Journal Article | Kim, DS, Burt, A, Ranchalis, J, Richter, RJ, Marshall, E, Rosenthal, E, Furlong, C and Jarvik, GP. 2012. Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids 2012:476316. PMCID:PMC3364586. |
R834514C004 (Final) |
not available |
| Journal Article | Kim, DS, Burt, AA, Crosslin, DR, Robertson, PD, Ranchalis, JE, Boyko, EJ, Nickerson, DA, Furlong, CE and Jarvik, GP. 2013. Novel common and rare genetic determinants of paraoxonase activity:FTO, SERPINA12, and ITGAL. J Lipid Res. 54(2):552-60. PMCID:PMC3588879. |
R834514C004 (Final) |
not available |
| Journal Article | Costa, LG, Giordano, G, Cole, TB, Marsillach, J and Furlong, CE. 2013. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology. 307(10):115-122. PMCID:PMC3516631. |
R834514C004 (Final) |
not available |
| Journal Article | Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Furlong, CE. 2013. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact 203(1):85-90. |
R834514C004 (Final) |
not available |
| Journal Article | Costa, LG, Tait, L, de Laat, R, Dao, K, Giordano, G, Pellacani, C, Cole, TB and Furlong, CE. 2013. Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin:a mechanism of neuroprotection? Neurochem Res. 38(9):1809-18. 3735620. |
R834514C004 (Final) |
not available |
| Journal Article | Costa, LG, de Laat, R, Dao, K, Pellacani, C, Cole, TB and Furlong, CE. 2013. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology. 3942372. |
R834514C004 (Final) |
not available |
| Journal Article | Cole, TB, Li, WF, Co, AL, Hay, AM, MacDonald, JW, Bammler, TK, Farin, FM, Costa, LG and Furlong, CE. 2014. Repeated Gestational Exposure of Mice to Chlorpyrifos Oxon is Associated with Paraoxonase 1 (PON1)-Modulated Effects in Maternal and Fetal Tissues. Toxicol Sci. |
R834514C004 (Final) |
not available |
| Journal Article | Furlong CE, Marsillach J, Jarvik GP, Costa LG. 2016. Paraoxonases-1,-2 and-3:What are their functions? Chem Biol Interact. doi:10.1016/j.cbi.2016.05.036. PMID:27238723. |
R834513C003 (2016) R834514C004 (Final) |
not available |
| Journal Article | Garrick JM, Dao K, de Laat R, Elsworth J, Cole TB, Marsillach J, Furlong CE, Costa LG. 2016. Developmental expression of paraoxonase 2. Chem Biol Interact. pii:S0009-2797(16)30116-8. doi:10.1016/j.cbi.2016.04.001. PMID:27062895. |
R834514C004 (Final) |
not available |
| Journal Article | Marsillach J, Costa LG, Furlong CE. 2016. Paraoxonase-1 and Early-Life Environmental Exposures. Ann Glob Health. 82(1):100-10. PMID:27325068; PMCID:PMC4916371. |
R834514C004 (Final) |
not available |
| Journal Article | Cole, T.B., J.C. Fisher, T.M. Burbacher, L.G. Costa, and C.E. Furlong, Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol, 2012. 34(3):p. 311-322. |
R834514C004 (Final) R834798C003 (Final) |
not available |
| Journal Article | Burton C, Marsillach J, Zhang YS, Zhao W, Zheng X. Bioanalysis. 2015;7(13):1667-73. doi:10.4155/bio.15.90. Epub 2015 Jul 7** Judit Marsillach selected as a finalist for the Young Investigator Award to identify and reward promising early career researchers in the community. |
R834514C004 (Final) |
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| Journal Article | Furlong, C.E., R.J. Richter, L.G. Costa, and G.P. Jarvik, Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics, in Chapter 9:Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. 2012, American Chemical Society:Available at:http://pubs.acs.org/doi/abs/10.1021/bk-2012-1099.ch009. p. 133-147. |
R834514C004 (Final) |
not available |
| Journal Article | Costa, L.G., G. Giordano, and C.E. Furlong, Pharmacological and dietary modulators of paraxonase 1 (PON1) activity and expression:the hunt goes on. Biochem Pharmacol, 2011. 81(3):p. 337-344. PMCID3077125. |
R834514C004 (Final) |
not available |
| Journal Article | Kim, D.S., A. Burt, J. Ranchalis, R.J. Richter, E. Marshall, E. Rosenthal, C. Furlong, and G.P. Jarvik, Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids, 2012. 2012(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364586/pdf/JL2012-476316.pdf). |
R834514C004 (Final) |
not available |
| Journal Article | Kim, D.S., A.A. Burt, J.E. Ranchalis, R.J. Richter, J.K. Marshall, K.S. Nakayama, E.R. Jarvik, J.F. Eintracht, E.A. Rosenthal, C.E. Furlong, and G.P. Jarvik, Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res, 2012. 53(11):p. 2450-8. |
R834514C004 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.