Grantee Research Project Results
Publications Details for Grant Number R835738C003
Organotypic Models of Mammalian Liver as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
Other Views
- All
Publications - Selected
Publication Types - Journal
Articles - Publications Submitted
After Final Report - Redisplay this page with
Reference Title, Journal, and Author Columns - Display this Page
in RIS Format
| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ. Primary mouse airway epithelial cells are resistant to silver nanoparticles. The Toxicologist 2016;150(Suppl 1):10. |
R835738C001 (2015) R835738C003 (2017) |
|
| Abstract | Chang S, Voellinger JL, White C, Kelly EJ, Eaton DL. A tissue-engineered rat/human liver microphysiological system for drug and chemical testing. The Toxicologist 2015;144(S-1):151. |
R835738 (2016) R835738 (2017) R835738C003 (2015) |
|
| Journal Article | Chang S-Y, Weber EJ, Van Ness KP, Eaton DL, Kelly EJ. Liver and kidney on chips: microphysiological models to understand transporter function. Clinical Pharmacology & Therapeutics 2016;100(5):464-478. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C003 (2016) R835738C003 (2017) R835738C005 (2017) |
|
| Journal Article | Chang S-Y, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight 2017;2(22):e95978 (15 pp.). |
R835738C003 (2017) R835738C005 (2017) |
|
| Journal Article | Chang S-Y, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicology In Vitro 2017;40:170-183. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C003 (2016) R835738C003 (2017) |
|
| Journal Article | Melnikov F, Botta D, White CC, Schmuck SC, Schaupp CM, Gallagher EP, Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, Kostal J and Kavanagh TJ. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chemical Research in Toxicology2019:32(3);421-436 |
R835738C001 (2018) R835738C003 (2018) R835738C004 (2018) |
|
| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). |
R835736 (2015) R835736 (2016) R835736C004 (2016) R835736C005 (2016) R835738 (2016) R835738C003 (2017) R835738C005 (2017) |
|
| Presentation | Botta D, White CC, Melnikov F, Schaupp CM, Gallagher EG, Brooks BW, Kostal J, Voutchkova-Kostal, AM, Anastas PT and Kavanagh TJ. Using immortalized hepatocytes from wild-type and Gclm knock out mice to investigate the relative toxicity and Nrf2 activation of SN2 reactive electrophiles. Presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835738 (2017) R835738C003 (2017) R835738C003 (2018) |
not available |
| Presentation | Chang SY, Weber E, Kelly EJ, Eaton DL. Microphysiological systems to identify organ-organ interactions in toxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Pacific Northwest Association of Toxicologists Annual Meeting, Woodinville, WA, September 17-18, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C003 (2015) R835738C005 (2017) |
not available |
| Presentation | Chang SY, Weber E, Neumann T, Kelly EJ, Eaton DL. Microphysiological Systems (MPS) to identify organ-organ interactions in tToxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C003 (2015) R835738C005 (2017) |
not available |
| Presentation | Eaton D. New frontiers for linked microphysiological systems: integrated liver-kidney systems on a chip. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
not available |
| Presentation | Faustman E, French E, Eaton D, Kelly E, Kavanagh T. Using systems based approaches for refinement, integration and translation. Minicourse presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2018) R835738C003 (2018) |
not available |
| Presentation | Kavanagh TJ, Schaupp CM, Botta D, Schmuck S, White CC, Chisholm C. Measuring chemically-induced oxidative stress in genetically modified cultured mammalian liver cells. Presented at the Northwest Green Chemistry Conference, Troutdale, OR, April 23-24, 2015. |
R835738 (2016) R835738 (2017) R835738C003 (2015) |
not available |
| Presentation | Kavanagh T. Educational tools for designing safer chemicals and predicting toxicity. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
not available |
| Presentation | Kavanagh T. Experiences with collaborative cross for assessing gene X environment interactions for engineered nanomaterials: can we capture human variability in vitro-lessons from the Predictive Toxicology Center. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C003 (2018) R835738C005 (2017) |
not available |
| Presentation | Kelly E. Bioengineered ex vivo models of human organs for predictive toxicity testing. Presented at the New England Drug Metabolism Discussion Group Meeting, Walkersville, MD, December 6, 2017 |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
not available |
| Presentation | White CC, Botta D, Schaupp CM, Kavanagh TJ. Toxicological assessment of glutathione content, mitochondrial membrane potential and cardiolipin in an immortalized glutathione-deficient mouse hepatocyte cell line. Presented at the 32nd Congress of the International Society for Advancement of Cytometry, Boston, MA, June 10-14, 2017. |
R835738 (2016) R835738 (2017) R835738C003 (2018) |
not available |
| Presentation | Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill D and Kavanagh TJ (2018). Initial Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain iPSCs. Presented at the U.S EPA:3rd Annual STAR Organotypic Culture Models (OCM) Progress Review Meeting, Durham, NC. |
R835738C003 (2018) R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Botta D, Wang L, White CC, Popp J, Farris L, Lewis LA, Lynch RM, Bammler TK, Faustman EM, Rusyn I, Threadgill DW, Kavanagh TJ. Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain Induced Pluripotent Stem Cells. Society of Toxicology Annual Meeting, Baltimore, MD (2019). |
R835738C003 (2018) |
not available |
| Presentation | Kavanagh TJ, Botta D, White CC, Ness KP, Eaton DL, Faustman EM, Kelly EJ, Melnikov F, Anastas P, Voutchkova-Kostal A, Kostal J, Popp J, Farris L, Rusyn I, Threadgill D (2018). Role of Interindividual and Genetic Differences in Response of Human and Mouse Hepatocytes to Chemical Stressors. Presented at the U.S EPA:3rd Annual STAR Organotypic Culture Models (OCM) Progress Review Meeting, Durham, NC. |
R835738C003 (2018) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.