Grantee Research Project Results
Publications Details for Grant Number R835736C004
Organotypic Liver Model for Predictive Human Toxicology and Metabolism
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. The MicroPhysiology Systems Database for analyzing and modeling compound interactions with human and animal organ models. Applied In Vitro Toxicology 2016;2(2):103-117. |
R835736 (2015) R835736 (2016) R835736C004 (2017) |
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| Journal Article | Lee-Montiel FT, George SM, Gough AH, Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL. “Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems. Exp Biol Med 2017;242(16):1617-1632. |
R835736C004 (2018) |
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| Journal Article | Li X, George SM, Vernetti L, Gough AH, Taylor DL. A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Lab on a Chip 2018;21;18(17):2614-2631 |
R835736C004 (2018) |
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| Journal Article | Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL. Fluorescent protein biosensors applied to microphysiological systems. Experimental Biology and Medicine 2015;240(6):795-808. |
R835736 (2015) R835736 (2016) R835736C004 (2015) R835736C004 (2016) |
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| Journal Article | Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP. Pre-clinical and clinical investigations of metabolic zonation in liver diseases: the potential of microphysiology systems. Experimental Biology and Medicine 2017;242(16):1605-1616. |
R835736 (2017) R835736C004 (2017) |
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| Journal Article | Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Experimental Biology and Medicine 2016;241(1):101-114. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C004 (2015) R835736C004 (2016) R835736C004 (2017) R835736C004 (2018) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). |
R835736 (2017) R835736C004 (2018) R835738C002 (2017) R835738C005 (2017) |
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| Journal Article | Vernetti LA, Vogt A, Gough A, Taylor DL. Evolution of experimental models of the liver to predict human drug hepatotoxicity and efficacy. Clinics in Liver Disease 2017;21(1):197-214. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C004 (2017) R835736C004 (2018) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). |
R835736C004 (2017) R835738 (2017) R835738C002 (2016) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). |
R835736 (2015) R835736 (2016) R835736C004 (2016) R835736C005 (2016) R835738 (2016) R835738C003 (2017) R835738C005 (2017) |
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| Presentation | Taylor DL. Evolution of a human liver MPS platform. Presented at the Society for Experimental Biology and Medicine (SEBM) Annual Meeting, Chicago, IL, April 24, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Spatial tumor biology for phenotyping, immunotyping and recapitulating tumor microenvironments. Presented at the Melanoma Specialized Programs of Research Excellence (SPORE) Meeting at the University of Pittsburgh, Pittsburgh, PA, August 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL, Vernetti LA. Functional application of liver organotypic culture models. Presented via the EPA Virtual Tissue Models Meeting Webinar, February 22, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented at the Eli Lilly meeting, Indianapolis, IN, July 24, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. The evolution, challenges and recent application of high content screening. Presented at the Servier Pharmaceutical Company Presentation, Paris, France, June 9, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. The next technology wave: biosensors, extreme computing, and organ chips for predicting cardiovascular toxicity. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Quantitative systems pharmacology of liver diseases: human liver microphysiology system (MPS). Presented at the Astra-Zeneca Review of AZ MPS Program, Boston, MA, March 23, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Evolution of a human liver microphysiology system. Presented at the National Center for Advancing Translational Sciences (NCATS), The National Institues of Health, Bethesda, MD, May 5, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. The application of quantitative systems pharmacology to investigate liver diseases and toxicology. Presented at the Tsinghua Seminar, Pittsburgh, PA, May 8, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Investigating human liver disease progression with 3D microfluidic models. Presented at the High-Content Analysis and Phenotypic Screening Conference, Boston, MA, November 6, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. [title not provided]. Presented at the National Academy of Sciences Roundtable, Washington, DC, October 5, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL, Gough A. A human liver-on-a-chip as a key experimental component of the application of quantitative systems pharmacology. Presented at the Roche Seminar, Basel, Switzerland, October 6, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Quantitative systems pharmacology (QSP) in drug discovery. Presented at the NCI Online Principles of Clinical Pharmacology Course, Pittsburgh, PA, September 18, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Metastatic breast cancer explored in a human, 3D, microfluidic liver chip. Presented at the Charles River Conference, Boston, MA, September 26, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented via the Health and Environmental Sciences Institute Webinar, September 5, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor, DL. A Human Liver Microphysiology System for Drug Discovery and development. Presented at North American meeting of the International Society for the Study of Xenobiotics, Montreal, Canada. July 16th-18, 2018. |
R835736C004 (2018) |
not available |
| Presentation | Taylor, DL. Application of quantitative systems pharmacology (QSP) and human microphysiology systems (MPS) to develop therapeutic strategies for liver diseases, Lawrenceville, New Jersey. October 26, 2018. |
R835736C004 (2018) |
not available |
| Presentation | Taylor, DL. Human Microphysiology Systems as a Critical Component of Quantitative Systems Pharmacology Applied to Drug Discovery and Development. Presented at DILI Sym Meeting, Chapel Hill, North Carolina. September 11, 2018. |
R835736C004 (2018) |
not available |
| Presentation | Taylor DL. The Evolution of Human Experimental Models for Drug Discovery/Development and Precision medicine:Different Model Types, Reproducibility, Applications and Future Impact. Presented at NIH workshop, Pittsburgh, Pennsylvania. September 13th-14th, 2018. |
R835736C004 (2018) |
not available |
| Presentation | Vernetti LA. Development of an integrated liver microphysiological system. Presented at the 20th North American International Society for the Study of Xenobiotics (ISSX) Meeting, Orlando, FL, October 18-22, 2015. |
R835736 (2016) R835736 (2017) R835736C004 (2018) |
not available |
| Presentation | Vernetti LA. Predicting human toxicity from MOA based high content imaging in 2D and 3D microphysiology systems. Presented at Thermo Fisher, Princeton, NJ, October 13, 2016. |
R835736 (2016) R835736 (2017) R835736C004 (2018) |
not available |
| Presentation | Vernetti LA, Gough A, Bergenthal L, Karcher S, Shun T, Wolter Q, Gavlock D, Reese C, Schurdak M, Taylor DL. Poster Presentation:The Human Liver Acinus MicroPhysiology System (LAMPS) for Analyzing and Ranking the Hepatotoxicity Potential of Compounds and as a Metabolic Component for Integration with other OCM. Presented at 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Reviews. May 22 and 23, 2018. |
R835736C004 (2018) |
not available |
| Presentation | Vernetti L. Application and challenges to constructing a competent human liver on a chip. Presented at the Society of Toxicology 2016 Satellite Meeting 3D or Not 3D: That is the [Predictive Toxicology] Question, New Orleans, LA, March 17, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C004 (2018) |
not available |
| Presentation | Taylor, DL, Gordon Research Conference on Toxicology, “Functional Coupling of Liver Microphysiological Systems,” Easton, Massachusetts. June 10th-15, 2018. ". |
R835736C004 (2018) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.