Grantee Research Project Results
Publications Details for Grant Number R835000
A Multi-scale Dose-response Model of AHR Toxicity Pathway Activation in the Human Liver
RFA:
Computational Toxicology: Biologically-Based Multi-Scale Modeling (2010)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Book Chapter | Bhattacharya S, Zhang Q, Roth RA, Andersen ME. The role of computational systems biology models in toxicity testing in the 21st century: an example with predictive multi-scale models of the liver. In: Wilson AGE, ed. New Horizons in Predictive Toxicology: Current Status and Application. Cambridge, UK: Royal Society of Chemistry, 2012, Chapter 24, pp. 614-691. |
R835000 (2012) R835000 (Final) |
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| Journal Article | Bhattacharya S, Shoda LK, Zhang Q, Woods CG, Howell BA, Siler SQ, Woodhead JL, Yang Y, McMullen P, Watkins PB, Andersen ME. Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches. Frontiers in Physiology 2012;3:462. |
R835000 (2012) R835000 (Final) |
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| Journal Article | McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME. A map of the PPARα transcription regulatory network for primary human hepatocytes. Chemico-Biological Interactions 2014;209:14-24. |
R835000 (2013) R835000 (Final) |
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| Presentation | Bhattacharya S, Woods CG, Yarborough KM, Efremenko A, Pluta L, Lu P, Dong J, Pi J, Andersen ME. A provisional regulatory network of PPARα-mediated transcription in primary human hepatocytes. Presented at the Wellcome Trust Functional Genomics and Systems Biology Conference, Hinxton, United Kingdom, November 29-December 1, 2011. |
R835000 (2011) R835000 (Final) |
not available |
| Presentation | Bhattacharya S, McMullen P, Woods CG, Yarborough KM, Efremenko A, Pluta L, Lu P, Dong J, Pi J, Andersen ME. A provisional regulatory network of PPARα-mediated toxicity pathways in primary human hepatocytes. Presented at the North Carolina Society of Toxicology Spring Meeting, Research Triangle Park, NC, February 23, 2012. |
R835000 (2012) |
not available |
| Presentation | Bhattacharya S, McMullen P, Woods CG, Yarborough KM, Efremenko A, Pluta L, Lu P, Dong J, Pi J, Thomas RS, Andersen ME. A provisional regulatory network of PPAR-mediated transcription in primary human hepatocytes. Poster presented at Xenobiotic Receptors: 31st Summer Symposium in Molecular Biology, Penn State University, State College, PA, July 22-24, 2012. |
R835000 (2012) R835000 (Final) |
not available |
| Presentation | Bhattacharya S, Woods CG, Yarborough KM, Efremenko A, Pluta L, Lu P, Dong J, Pi J, Andersen ME. A provisional regulatory network of PPARα-mediated transcription in primary human hepatocytes. Poster presented at the Society of Toxicology Annual Meeting, San Franscisco, CA, March 11-15, 2012. |
R835000 (2012) |
not available |
| Presentation | Bhattacharya S, McMullen PD, Pendse S, Andersen ME. A multiscale mechanistic model of TCDD-induced toxicity for assessing expected dose-responses for adverse outcome pathways in liver. Poster presented at the Society of Toxicology (SOT) Annual Meeting, Phoenix, AZ, March 24-27, 2014. |
R835000 (Final) |
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| Presentation | Bhattacharya S, McMullen PD, Pendse S, Andersen ME. A multiscale virtual tissue model of the liver lobule to assess zonal heterogeneity in AhR adverse outcome pathway-induced biological responses. Poster presented at the Society of Toxicology (SOT) Annual Meeting, San Diego, CA, March 22-26, 2015. |
R835000 (Final) |
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| Presentation | McMullen PD, Andersen ME, Bhattacharya S. A multiscale dose-response model of AhR toxicity pathway activation in the human liver. Poster presented at the Society of Toxicology Annual Meeting, San Antonio, TX, March 10-14, 2013. |
R835000 (2013) R835000 (Final) |
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| Presentation | McMullen PD, Bhattacharya S, Woods CG, Sun B, Pendse S, LeCluyse EL, Clewell RA, Andersen ME. Species specificity of the peroxisome proliferator response in primary hepatocytes. Poster presented at the Society of Toxicology Annual Meeting, San Antonio, TX, March 10-14, 2013. |
R835000 (2013) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.